328541-79-3
328541-79-3
Chemical Structure
GlyH-101
- CAS No.: 328541-79-3
- Formula:C19H15Br2N3O3
- Molecular Weight:493.15
IUPAC Name: (E)-N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(naphthalen-2-ylamino)acetohydrazide
InChIKey: RMBDLOATEPYBSI-NUGSKGIGSA-N
SMILES: O=C(N/N=C/C1=CC(Br)=C(O)C(Br)=C1O)CNC2=CC3=CC=CC=C3C=C2
Biological Activity: GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GlyH-101 | 99.68% | GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-168483FTO-IN-13 -
Similarity Score 0.60
HY-119082(E/Z)-VU0029767 -
Similarity Score 0.60
HY-119082AVU0029767 -
Similarity Score 0.59
HY-24547HpFabZ-IN-1 -
Similarity Score 0.56
HY-13863Hydroxy-Dynasore -
Similarity Score 0.55
HY-15586L67 -
Similarity Score 0.55
HY-15304RDynasore (Standard) -
Similarity Score 0.55
HY-W514721D13 -
Similarity Score 0.54
HY-155673SLU-PP-332 -
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References
- [1]. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37. [Content Brief]
- [2]. Kelly M, et al. Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther. 2010 Apr;333(1):60-9. [Content Brief]
