1. Membrane Transporter/Ion Channel
    Autophagy
  2. CFTR
    Autophagy
  3. Elexacaftor

Elexacaftor (Synonyms: VX-445)

Cat. No.: HY-111772 Purity: 99.77%
Handling Instructions

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.

For research use only. We do not sell to patients.

Elexacaftor Chemical Structure

Elexacaftor Chemical Structure

CAS No. : 2216712-66-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1289 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4500 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].

IC50 & Target

CFTR[1].

In Vitro

Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function. Elexacaftor (VX-445) has the potential to treat cystic fibrosis. VX-445-Tezacaftor-VX-770 significantly improves Phe508del CFTR protein processing, trafficking, and chloride transport to a greater extent than any two of these agents in dual combination[2].

Molecular Weight

597.65

Formula

C₂₆H₃₄F₃N₇O₄S

CAS No.

2216712-66-0

SMILES

CC1(C)C[[email protected]](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (209.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6732 mL 8.3661 mL 16.7322 mL
5 mM 0.3346 mL 1.6732 mL 3.3464 mL
10 mM 0.1673 mL 0.8366 mL 1.6732 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ElexacaftorVX-445VX445VX 445CFTRAutophagyCystic fibrosis transmembrane conductance regulatorCysticFibrosisInhibitorinhibitorinhibit

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