2. Membrane Transporter/Ion Channel Autophagy
  3. CFTR Autophagy
  4. Elexacaftor

Elexacaftor  (Synonyms: VX-445)

Cat. No.: HY-111772 Purity: 99.50%
COA Handling Instructions

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.

For research use only. We do not sell to patients.

Elexacaftor Chemical Structure

Elexacaftor Chemical Structure

CAS No. : 2216712-66-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 500 In-stock
Solution
10 mM * 1 mL in DMSO USD 500 In-stock
Solid
1 mg USD 110 In-stock
5 mg USD 380 In-stock
10 mg USD 610 In-stock
50 mg USD 1850 In-stock
100 mg USD 2960 In-stock
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Customer Review

Based on 21 publication(s) in Google Scholar

Other Forms of Elexacaftor:

Elexacaftor Related Antibodies

Top Publications Citing Use of Products

    Elexacaftor purchased from MedChemExpress. Usage Cited in: J Cyst Fibros. 2022.

    Elexacaftor/Tezacaftor (elexa/teza; 3 μM/10 μM; 24 h) combination causes a significant increase in the expression of the mature protein, with no changes in the expression of the immature, core-glycosylated form (B band) in Epithelia.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].

    IC50 & Target

    CFTR[1].
    In Vitro

    Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function. Elexacaftor (VX-445) has the potential to treat cystic fibrosis. VX-445-Tezacaftor-VX-770 significantly improves Phe508del CFTR protein processing, trafficking, and chloride transport to a greater extent than any two of these agents in dual combination[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Elexacaftor Related Antibodies
    Clinical Trial
    Molecular Weight

    597.65

    Appearance

    Solid

    Formula

    C26H34F3N7O4S
    CAS No.
    SMILES

    CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (209.15 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6732 mL 8.3661 mL 16.7322 mL
    5 mM 0.3346 mL 1.6732 mL 3.3464 mL
    10 mM 0.1673 mL 0.8366 mL 1.6732 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
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    • If you have published this work, please enter the PubMed ID.
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    Elexacaftor Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Elexacaftor2216712-66-0VX-445VX445VX 445CFTRAutophagyCystic fibrosis transmembrane conductance regulatorCysticFibrosisInhibitorinhibitorinhibit

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