1. Membrane Transporter/Ion Channel
  2. CFTR
  3. CFTR corrector 4

CFTR corrector 4 

Cat. No.: HY-135279
Handling Instructions

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.

For research use only. We do not sell to patients.

CFTR corrector 4 Chemical Structure

CFTR corrector 4 Chemical Structure

CAS No. : 1918142-34-3

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Description

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1].

IC50 & Target

EC50:130 nM (CFTR)[1]

In Vitro

CFTR corrector 4 possesses high potency and efficacy with a EC50 of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log D, indicating high lipophilicity. HBE-TECC: (Human Bronchial Epithelial-Trans-Epithelial Current Clamp) assay[1].
CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC50 value 130 nM in the cell surface expression (CSE-HRP) assay[1].

Molecular Weight

539.52

Formula

C₂₉H₂₇F₂NO₇

CAS No.

1918142-34-3

SMILES

O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)N[[email protected]@H]4C[[email protected]](C5=CC=C(OC)C(OC)=C5)OC6=CC(OC)=CC=C46

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CFTR corrector 4CFTR corrector4CFTR corrector-4CFTRCystic fibrosis transmembrane conductance regulatorCysticFibrosisInhibitorinhibitorinhibit

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CFTR corrector 4
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