NJH-2-056
Based on 1 Customer Validation
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research.
For research use only. We do not sell to patients.
- Purity: 98.31%
- CAS No.: 2858812-69-6
- Formula: C41H40F2N6O8
- Molecular Weight:782.79
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
Chemical Information
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CAS No. 2858812-69-6
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Appearance Solid
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Molecular Weight 782.79
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Formula C41H40F2N6O8
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Color Off-white to pink
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SMILES
C=CC(N1CCN(C(C1)=O)C2=CC=C(O2)CCC(NCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (127.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2775 mL | 6.3874 mL | 12.7748 mL | 31.9370 mL |
| 5 mM | 0.2555 mL | 1.2775 mL | 2.5550 mL | 6.3874 mL | |
| 10 mM | 0.1277 mL | 0.6387 mL | 1.2775 mL | 3.1937 mL | |
| 15 mM | 0.0852 mL | 0.4258 mL | 0.8517 mL | 2.1291 mL | |
| 20 mM | 0.0639 mL | 0.3194 mL | 0.6387 mL | 1.5969 mL | |
| 25 mM | 0.0511 mL | 0.2555 mL | 0.5110 mL | 1.2775 mL | |
| 30 mM | 0.0426 mL | 0.2129 mL | 0.4258 mL | 1.0646 mL | |
| 40 mM | 0.0319 mL | 0.1597 mL | 0.3194 mL | 0.7984 mL | |
| 50 mM | 0.0255 mL | 0.1277 mL | 0.2555 mL | 0.6387 mL | |
| 60 mM | 0.0213 mL | 0.1065 mL | 0.2129 mL | 0.5323 mL | |
| 80 mM | 0.0160 mL | 0.0798 mL | 0.1597 mL | 0.3992 mL | |
| 100 mM | 0.0128 mL | 0.0639 mL | 0.1277 mL | 0.3194 mL |