2. PROTAC Membrane Transporter/Ion Channel
  3. PROTACs CFTR
  4. NJH-2-056

NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research.

For research use only. We do not sell to patients.

NJH-2-056 Chemical Structure

NJH-2-056 Chemical Structure

CAS No. : 2858812-69-6

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5 mg USD 680 In-stock
10 mg USD 1100 In-stock
25 mg USD 2250 In-stock
50 mg USD 3500 In-stock
100 mg USD 5600 In-stock
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Based on 1 publication(s) in Google Scholar

NJH-2-056 Related Antibodies

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Description

NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research[1].

Molecular Weight

782.79

Formula

C41H40F2N6O8
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

C=CC(N1CCN(C(C1)=O)C2=CC=C(O2)CCC(NCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (127.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2775 mL 6.3874 mL 12.7748 mL
5 mM 0.2555 mL 1.2775 mL 2.5550 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2775 mL 6.3874 mL 12.7748 mL 31.9370 mL
5 mM 0.2555 mL 1.2775 mL 2.5550 mL 6.3874 mL
10 mM 0.1277 mL 0.6387 mL 1.2775 mL 3.1937 mL
15 mM 0.0852 mL 0.4258 mL 0.8517 mL 2.1291 mL
20 mM 0.0639 mL 0.3194 mL 0.6387 mL 1.5969 mL
25 mM 0.0511 mL 0.2555 mL 0.5110 mL 1.2775 mL
30 mM 0.0426 mL 0.2129 mL 0.4258 mL 1.0646 mL
40 mM 0.0319 mL 0.1597 mL 0.3194 mL 0.7984 mL
50 mM 0.0255 mL 0.1277 mL 0.2555 mL 0.6387 mL
60 mM 0.0213 mL 0.1065 mL 0.2129 mL 0.5323 mL
80 mM 0.0160 mL 0.0798 mL 0.1597 mL 0.3992 mL
100 mM 0.0128 mL 0.0639 mL 0.1277 mL 0.3194 mL
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NJH-2-056 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NJH-2-0562858812-69-6PROTACsCFTRCystic fibrosis transmembrane conductance regulatorcystic fibrosisDUBTACdeubiquitinase-targeting chimeraInhibitorinhibitorinhibit

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