XAGE3 - X antigen family member 3 Gene

Also Known as PLAC6; GAGED4; XAGE-3; pp9012; CT12.3a; CT12.3b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 170626

Summary

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of Tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting Cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) Antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Restricted expression toward placenta (RPKM 81.9).

XAGE3 Products (2)

mRNA Protein Name
NM_130776.2 NP_570132.1 X antigen family member 3
NM_133179.3 NP_573440.1 X antigen family member 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23275563 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XAGE3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
XAGE3 Q8WTP9 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
Intra
XAGE3 Q8WTP9 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
XAGE3 Q8WTP9 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
XAGE3 Q8WTP9 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
XAGE3 Q8WTP9 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
XAGE3 Q8WTP9 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra
XAGE3 Q8WTP9 GMCL1 Homo sapiens Q96IK5
Anti Tag CoIP
33961781
Intra
XAGE3 Q8WTP9 GMCL1 Homo sapiens Q96IK5
Anti Tag CoIP
28514442
Intra
XAGE3 Q8WTP9 GMCL1 Homo sapiens Q96IK5
Y2H Array
31515488
Intra
XAGE3 Q8WTP9 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra
XAGE3 Q8WTP9 HTT Homo sapiens P42858
Lumier
23275563
Intra
XAGE3 Q8WTP9 HTT Homo sapiens P42858
Y2H Prey Pooling
23275563
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01349 BAGE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07493 LAGE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09975 PAGE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown