1. Membrane Transporter/Ion Channel
    Autophagy
  2. CFTR
    Autophagy
  3. IOWH-032

IOWH-032 

Cat. No.: HY-18337 Purity: 99.66%
Handling Instructions

IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.

For research use only. We do not sell to patients.

IOWH-032 Chemical Structure

IOWH-032 Chemical Structure

CAS No. : 1191252-49-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 160 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
500 mg USD 750 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays. IC50 value: 1.01 uM (CHO-CFTR FLIPR) [1] Target: CFTR Profiling of iOWH032 showed it to be a CFTR inhibitor in T84 and CHO-CFTR cell based assays. It also demonstrated statistical significant inhibition at both 100 g & 10 g doses in the mouse closed-loop model. iOWH032 was further profiled in a cecetomized rat model. iOWH032 reduced the fecal output index by ~70%, compared to vehicle (cholera toxin), up to 8 hours after a single 5 mg/kg po dose.

Clinical Trial
Molecular Weight

545.18

Formula

C₂₂H₁₅Br₂N₃O₄

CAS No.
SMILES

BrC1=C(O)C(Br)=CC(C2=NOC(C(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=O)=N2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (183.43 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8343 mL 9.1713 mL 18.3426 mL
5 mM 0.3669 mL 1.8343 mL 3.6685 mL
10 mM 0.1834 mL 0.9171 mL 1.8343 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IOWH-032IOWH032IOWH 032CFTRAutophagyCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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Product Name:
IOWH-032
Cat. No.:
HY-18337
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