1. Membrane Transporter/Ion Channel
  2. CFTR
  3. Ivacaftor-D9

Ivacaftor-D9 (Synonyms: CTP-656)

Cat. No.: HY-13017S
Handling Instructions

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research.

For research use only. We do not sell to patients.

Ivacaftor-D9 Chemical Structure

Ivacaftor-D9 Chemical Structure

CAS No. : 1413431-07-8

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Description

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

In Vivo

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

401.55

Formula

C₂₄H₁₉D₉N₂O₃

CAS No.

1413431-07-8

SMILES

CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ivacaftor-D9CTP-656CTP656CTP 656CFTRCystic fibrosis transmembrane conductance regulatorcystic fibrosismodulatorInhibitorinhibitorinhibit

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Ivacaftor-D9
Cat. No.:
HY-13017S
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