SHANK2 - Shank2 SH3 and multiple ankyrin repeat domains 2 Gene

Also Known as CortBP1; ProSAP1; Spank-3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171093

Summary

Enables SH3 domain binding activity and protein C-terminus binding activity. A structural constituent of postsynaptic density. Involved in several processes, including adult locomotory behavior; associative learning; and social behavior. Located in several cellular components, including apical plasma membrane; cell projection membrane; and growth cone. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Apr 2022]

SHANK2 Products (4)

mRNA Protein Name
NM_001004133.1 NP_001004133.1 SH3 and multiple ankyrin repeat domains protein 2 isoform b
NM_133440.1 NP_597684.1 SH3 and multiple ankyrin repeat domains protein 2 isoform c
NM_133441.2 NP_597685.1 SH3 and multiple ankyrin repeat domains protein 2 isoform d
NM_201350.1 NP_958738.1 SH3 and multiple ankyrin repeat domains protein 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
15014124 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10958799 RGD
enables structural constituent of postsynaptic density IDA
IDA: Inferred from direct assay
21217644 RGD
enables structural constituent of postsynaptic density IMP
IMP: Inferred from mutant phenotype
21217644 RGD
Biological Process GO Annotation Evidence References Source
involved in adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
29970986 RGD
involved in associative learning IMP
IMP: Inferred from mutant phenotype
29970986 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
21217644 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
21217644 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15917299 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
29970986 RGD
involved in social behavior IMP
IMP: Inferred from mutant phenotype
29970986 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17244609 RGD
is active in asymmetric synapse IDA
IDA: Inferred from direct assay
10414979 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
15917299 RGD
located in ciliary membrane IDA
IDA: Inferred from direct assay
18596612 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10414979 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21217644 RGD
located in growth cone IDA
IDA: Inferred from direct assay
10958799 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
10414979 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10958799 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
10414979 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
21119615 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH3 and multiple ankyrin repeat domains protein 2

  • GKAP/SAPAP-interacting protein

  • SH3 and multiple ankyrin repeat domains protein 2-like

  • SH3/ankyrin domain gene 2

  • cortactin-binding protein 1

  • proline-rich synapse-associated protein 1

SHANK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Shank2 Q9QX74 CFTR Homo sapiens P13569
Y2H
14679199
Cross
Shank2 Q9QX74 CFTR Homo sapiens P13569
SPR
17244609
Intra
Shank2 Q9QX74 Plcb3 Rattus norvegicus Q99JE6
Y2H
15632121
Intra
Shank2 Q9QX74 Plcb3 Rattus norvegicus Q99JE6
Anti Bait CoIP
15632121
Cross
Shank2 Q9QX74 Arhgef7 Mus musculus Q9ES28-2
Anti Tag CoIP
12626503
Intra
Shank2 Q9QX74 Pde4d Rattus norvegicus P14270-8
Anti Bait CoIP
17244609
Intra
Shank2 Q9QX74 Pde4d Rattus norvegicus P14270-8
Pull Down
17244609
Intra
Shank2 Q9QX74 Slc9a3 Rattus norvegicus P26433
Anti Bait CoIP
20080968
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12851 SHANK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SHANK2 NCBI NCBI:22941