Slc9a3 - solute carrier family 9 member A3 Gene

Also Known as Nhe3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24784

Summary

Enables sodium:proton antiporter activity. Involved in several processes, including regulation of pH; response to glucocorticoid; and sodium ion transport. Located in apical plasma membrane and brush border membrane. Used to study hypertension. Biomarker of obesity and renovascular hypertension. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a3 Products (2)

mRNA Protein Name
NM_001414040.1 NP_001400969.1 sodium/hydrogen exchanger 3 precursor
NM_012654.3 NP_036786.2 sodium/hydrogen exchanger 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12576672 RGD
enables sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
11880335 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
15780093 RGD
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15113744 RGD
involved in regulation of pH IDA
IDA: Inferred from direct assay
15265811 RGD
involved in regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
15238256 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17095646 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
11880335 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12907430 RGD
located in brush border IDA
IDA: Inferred from direct assay
11880335 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
15238256 RGD
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
9442041 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 3

  • NHE-3

  • Na(+)/H(+) exchanger 3

  • Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive)

  • plasma membrane ion transport protein

  • solute carrier family 9 (sodium/hydrogen exchanger), member 3

  • solute carrier family

Slc9a3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc9a3 P26433 Arhgef7 Rattus norvegicus O55043
Anti Bait CoIP
20080968
Intra
Slc9a3 P26433 Shank2 Rattus norvegicus Q9QX74
SPR
16293618
Intra
Slc9a3 P26433 Shank2 Rattus norvegicus Q9QX74
Y2H
16293618
Intra
Slc9a3 P26433 Chp2 Rattus norvegicus Q810D1
IF
12576672
Intra
Slc9a3 P26433 Chp2 Rattus norvegicus Q810D1
Far-WB
12576672
Intra
Slc9a3 P26433 Chp2 Rattus norvegicus Q810D1
Pull Down
12576672
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13343 SLC9A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc9a3 NCBI NCBI:6550