ACOT8 - acyl-CoA thioesterase 8 Gene

Also Known as hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10005

About ACOT8

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,841,721-45,857,392 (from NCBI)

This gene has 13 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in adrenal (RPKM 10.6), brain (RPKM 10.3) and 25 other tissues.

Summary

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

ACOT8 Products (1)

mRNA	Protein	Name
NM_005469.4	NP_005460.2	acyl-coenzyme A thioesterase 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	10092594	GOA
NOT enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	9153233	GOA
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	9299485	GOA
enables medium-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	9153233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9153233	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acyl-CoA metabolic process	IDA IDA: Inferred from direct assay	9153233	GOA
involved in dicarboxylic acid catabolic process	IDA IDA: Inferred from direct assay	16141203	GOA
involved in negative regulation of CD4 production	IDA IDA: Inferred from direct assay	9153233	GOA
involved in peroxisome fission	IDA IDA: Inferred from direct assay	15194431	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in peroxisomal matrix	IDA IDA: Inferred from direct assay	10092594	GOA
located in peroxisomal matrix	IMP IMP: Inferred from mutant phenotype	14709540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT8 Protein Structure

4HBT_3

0
100
200
300
319 a.a.

Protein Preferred Names	Protein Names
acyl-coenzyme A thioesterase 8	HIV-Nef associated acyl-CoA thioesterase

ACOT8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACOT8	O14734	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	32296183
Intra	ACOT8	O14734	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	ACOT8	O14734	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	ACOT8	O14734	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	ACOT8	O14734	REL	Homo sapiens	Q04864	Y2H Array	25416956
Cross	ACOT8	O14734	nef	Human immunodeficiency virus	P04601	Y2H	9299485
Cross	ACOT8	O14734	nef	Human immunodeficiency virus	P04601	Pull Down	22190034
Cross	ACOT8	O14734	nef	Human immunodeficiency virus	P04601	Pull Down	9299485

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Non-Syndromic X-Linked Intellectual Disability 14	Mrx14
Flinders Island Spotted Fever	Fisf Thai Tick Typhus
Hypotrichosis 1	HYPT1 Hhs Hts Hypotrichosis Simplex Hypotrichosis Simplex, Generalized, Hereditary Hereditary Generalized Hypotrichosis Simplex Generalized Hypothricosis Simplex Hypotrichosis Simplex Hereditary Hypotrichosis, Type 1
Alpha-Methylacyl-Coa Racemase Deficiency	Amacr Deficiency AMACRD
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00180	ACOT8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ACOT8	VGNC	VGNC:37519
Felis catus	ACOT8	VGNC	VGNC:59520
Bos taurus	ACOT8	VGNC	VGNC:25550
Rattus norvegicus	ACOT8	RGD	RGD:70368
Macaca mulatta	ACOT8	VGNC	VGNC:69413
Mus musculus	ACOT8	MGD	MGI:2158201
Others	ACOT8	NCBI