UCCF-853

Cat. No.: HY-119179 Purity: 99.93%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

UCCF-853 is a CFTR modulator.

For research use only. We do not sell to patients.

UCCF-853 Chemical Structure

CAS No. : 625458-06-2

Size	Price	Stock	Quantity
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

UCCF-853 is a CFTR modulator^[1].

Molecular Weight

312.67

Formula

C₁₄H₈ClF₃N₂O

CAS No.

625458-06-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=C(C=C2N1)C(F)(F)F)C3=CC=CC(Cl)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (399.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1983 mL	15.9913 mL	31.9826 mL
5 mM	0.6397 mL	3.1983 mL	6.3965 mL
10 mM	0.3198 mL	1.5991 mL	3.1983 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (271 KB) SDS (0 KB)

COA (252 KB) HNMR (261 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Nicoletta Pedemonte, et al. Influence of cell background on pharmacological rescue of mutant CFTR. Am J Physiol Cell Physiol. 2010 Apr;298(4):C866-74. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1983 mL	15.9913 mL	31.9826 mL	79.9565 mL
	5 mM	0.6397 mL	3.1983 mL	6.3965 mL	15.9913 mL
	10 mM	0.3198 mL	1.5991 mL	3.1983 mL	7.9957 mL
	15 mM	0.2132 mL	1.0661 mL	2.1322 mL	5.3304 mL
	20 mM	0.1599 mL	0.7996 mL	1.5991 mL	3.9978 mL
	25 mM	0.1279 mL	0.6397 mL	1.2793 mL	3.1983 mL
	30 mM	0.1066 mL	0.5330 mL	1.0661 mL	2.6652 mL
	40 mM	0.0800 mL	0.3998 mL	0.7996 mL	1.9989 mL
	50 mM	0.0640 mL	0.3198 mL	0.6397 mL	1.5991 mL
	60 mM	0.0533 mL	0.2665 mL	0.5330 mL	1.3326 mL
	80 mM	0.0400 mL	0.1999 mL	0.3998 mL	0.9995 mL
	100 mM	0.0320 mL	0.1599 mL	0.3198 mL	0.7996 mL

UCCF-853 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCCF-853625458-06-2UCCF853UCCF 853CFTRCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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