1. Membrane Transporter/Ion Channel
  2. CFTR
  3. Posenacaftor sodium

Posenacaftor sodium (Synonyms: PTI-801 sodium)

Cat. No.: HY-109187A
Handling Instructions

Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF).

For research use only. We do not sell to patients.

Posenacaftor sodium Chemical Structure

Posenacaftor sodium Chemical Structure

CAS No. : 2095064-06-3

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Description

Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF)[1].

In Vitro

Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR)[1].
CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells.Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells[1].
Posenacaftor is a CFTR corrector, correctors are always designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

467.49

Formula

C₂₇H₂₆NNaO₅

CAS No.

2095064-06-3

SMILES

O=C(C1=CC(C2=C(C)C3=CC=CC=C3O2)=NC4=C(C)C=CC(O[[email protected]@H](C5CCOCC5)C)=C14)O[Na]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PosenacaftorPTI-801PTI801PTI 801CFTRCystic fibrosis transmembrane conductance regulatorcystic fibrosislung functionInhibitorinhibitorinhibit

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Posenacaftor sodium
Cat. No.:
HY-109187A
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