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DDX20 - DEAD-box helicase 20 Gene

Also Known as DP103; GEMIN3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11218

About DDX20

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,755,901-111,768,000 (from NCBI)

This gene has 21 transcripts (splice variants), 200 orthologues and 38 paralogues. Broad expression in testis (RPKM 58.2), bone marrow (RPKM 6.4) and 17 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]

DDX20 Products (1)

mRNA	Protein	Name
NM_007204.5	NP_009135.4	probable ATP-dependent RNA helicase DDX20

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12007404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11714716	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12007404	GOA
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16153597	GOA
involved in spliceosomal snRNP assembly	EXP EXP: Inferred from Experiment	12067652	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SMN complex	IDA IDA: Inferred from direct assay	17178713	GOA
part of SMN complex	IPI IPI: Inferred from physical interaction	17178713	GOA
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX20 Protein Structure

DEAD

Helicase_C

0
200
400
600
824 a.a.

Protein Preferred Names	Protein Names
probable ATP-dependent RNA helicase DDX20	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

DDX20 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDX20	Q9UHI6	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	DDX20	Q9UHI6	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	DDX20	Q9UHI6	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	DDX20	Q9UHI6	GDAP1	Homo sapiens	Q8TB36	Y2H Pooling	32814053
Intra	DDX20	Q9UHI6	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32814053
Intra	DDX20	Q9UHI6	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32814053
Intra	DDX20	Q9UHI6	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	DDX20	Q9UHI6	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	DDX20	Q9UHI6	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	DDX20	Q9UHI6	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	DDX20	Q9UHI6	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	DDX20	Q9UHI6	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	DDX20	Q9UHI6	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Anti Tag CoIP	28514442
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Anti Bait CoIP	11714716
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Y2H Prey Pooling	32296183
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Y2H Array	32296183
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Filter Binding	10725331
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Anti Bait CoIP	23752268
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Pull Down	10725331
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	Anti Tag CoIP	33961781
Intra	DDX20	Q9UHI6	GEMIN4	Homo sapiens	P57678	CoIP	10725331
Intra	DDX20	Q9UHI6	SMN1	Homo sapiens	Q16637	Anti Bait CoIP	23752268
Intra	DDX20	Q9UHI6	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	DDX20	Q9UHI6	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	DDX20	Q9UHI6	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	DDX20	Q9UHI6	SMN1	Homo sapiens	Q16637	Anti Bait CoIP	11714716
Intra	DDX20	Q9UHI6	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	DDX20	Q9UHI6	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	DDX20	Q9UHI6	A2M	Homo sapiens	P01023	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

DDX20 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82933	Gemin 3 Antibody (YA2678)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P84861	Gemin 3 Antibody (YA4558)	WB, ICC/IF, FC, ELISA	Human, Rat
HY-P84861A	Gemin 3 Antibody (YA4558)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Childhood Spinal Muscular Atrophy	Spinal Muscular Atrophies Of Childhood Survival Motor Neuron Spinal Muscular Atrophy
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03636	DDX20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDX20	RGD	RGD:621744
Macaca mulatta	DDX20	VGNC	VGNC:99881
Bos taurus	DDX20	VGNC	VGNC:27958
Canis familiaris	DDX20	VGNC	VGNC:39848
Felis catus	DDX20	VGNC	VGNC:61400
Mus musculus	DDX20	MGD	MGI:1858415
Others	DDX20	NCBI