CFTR potentiator 1
CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC50 value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR.
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- Formule: C18H18N4O3
- Masse moléculaire:338.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
| Route | Dose (mg/kg) | Tmax (h) | Cmax (ng/mL) | AUClast (h*ng/mL) | T1/2 (h) | CL (ml/min/kg) | Vss (1/kg) | %F |
| IP | 10 | 0.25 | 2617 | 2145 | 2.16 | - | - | - |
| PO | 10 | 0.25 | 1181 | 1211 | 1.24 | - | - | 60 |
| SC | 10 | 0.50 | 625 | 1512 | 1.36 | - | - | - |
| IV | 3 | - | 2354 | 610 | 1.78 | 81.51 | 2.49 | - |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 338.36
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Formule C18H18N4O3
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SMILES
NC1=NN(C([C@@H](COC2=CC=CC=C2)C)=O)C3=CC(C(N)=O)=CC=C31
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CFTR potentiator 1 Related Classifications
HY-161753 Related Classifications
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