YTHDF1 - YTH N6-methyladenosine RNA binding protein 1 Gene

Also Known as DF1; C20orf21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54915

About YTHDF1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,195,429-63,216,131 (from NCBI)

This gene has 2 transcripts (splice variants), 262 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 18.6), bone marrow (RPKM 15.2) and 25 other tissues.

Summary

Enables N6-methyladenosine-containing RNA binding activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Apr 2022]

YTHDF1 Products (1)

mRNA Protein Name
NM_017798.4 NP_060268.2 YTH domain-containing family protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
24284625 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28106072 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
26046440 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA destabilization IDA
IDA: Inferred from direct assay
32492408 GOA
involved in organelle assembly IDA
IDA: Inferred from direct assay
31292544 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
28106072 GOA
NOT involved in positive regulation of translational initiation IDA
IDA: Inferred from direct assay
32492408 GOA
involved in positive regulation of translational initiation IDA
IDA: Inferred from direct assay
26046440 GOA
involved in regulation of mRNA stability IDA
IDA: Inferred from direct assay
32492408 GOA
involved in stress granule assembly IDA
IDA: Inferred from direct assay
32451507 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
32492408 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
32492408 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
32451507 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDF1 Protein Structure

YTH

YTH: YT521-B-like domain (390 - 524)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

YTH domain-containing family protein 1

  • DACA-1

YTHDF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
YTHDF1 Q9BYJ9 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 C6orf15 Homo sapiens Q6UXA7
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 C6orf15 Homo sapiens Q6UXA7
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
Intra
YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 PRR32 Homo sapiens B1ATL7
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 PRR32 Homo sapiens B1ATL7
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 VPS37C Homo sapiens A5D8V6
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 YTHDF3 Homo sapiens Q7Z739
Anti Tag CoIP
33961781
Intra
YTHDF1 Q9BYJ9 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra
YTHDF1 Q9BYJ9 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Validated Y2H
32296183
Intra
YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 BATF2 Homo sapiens Q8N1L9
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 BATF2 Homo sapiens Q8N1L9
Y2H Array
32296183
Intra
YTHDF1 Q9BYJ9 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra
YTHDF1 Q9BYJ9 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

YTHDF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81684 YTHDF1 Antibody (YA1429) WB, IP Human, Hamster
HY-P81684A YTHDF1 Antibody (YA1429)(PBS only) WB, IP Human, Hamster
HY-P86545 YTHDF1 Antibody (YA6237) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Ocular Melanoma

  • Intraocular Melanoma

  • Uveal Melanoma

  • Eye Melanoma

  • Melanoma Of Eye

  • Melanoma Of The Uvea

  • Malignant Melanoma Of Eye
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176848 SKLB-Y13 Inhibitor 98.44% Unkown
HY-168610 YTH-IN-1 Inhibitor 98.66% Unkown
HY-RS15937 YTHDF1 Human Pre-designed siRNA Set A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus YTHDF1 VGNC VGNC:67151
Bos taurus YTHDF1 VGNC VGNC:37041
Canis familiaris YTHDF1 VGNC VGNC:48505
Macaca mulatta YTHDF1 VGNC VGNC:78988
Rattus norvegicus YTHDF1 RGD RGD:1308932
Mus musculus YTHDF1 MGD MGI:1917431
Others YTHDF1 NCBI