YTHDF3 - YTH N6-methyladenosine RNA binding protein 3 Gene

Also Known as DF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 253943

About YTHDF3

Cytogenetic location: 8q12.3 Genomic coordinates (GRCh38): 8:63,168,553-63,212,788 (from NCBI)

This gene has 16 transcripts (splice variants), 204 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 27.1), colon (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

YTHDF3 Products (7)

mRNA	Protein	Name
NM_001277813.2	NP_001264742.1	YTH domain-containing family protein 3 isoform b
NM_001277814.2	NP_001264743.1	YTH domain-containing family protein 3 isoform b
NM_001277815.2	NP_001264744.1	YTH domain-containing family protein 3 isoform c
NM_001277816.2	NP_001264745.1	YTH domain-containing family protein 3 isoform c
NM_001277817.2	NP_001264746.1	YTH domain-containing family protein 3 isoform c
NM_001277818.2	NP_001264747.1	YTH domain-containing family protein 3 isoform c
NM_152758.6	NP_689971.4	YTH domain-containing family protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	22575960	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	32194978	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22190034	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	28106076	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA destabilization	IDA IDA: Inferred from direct assay	32492408	GOA
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	28106072	GOA
involved in organelle assembly	IDA IDA: Inferred from direct assay	31292544	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	28106072	GOA
NOT involved in positive regulation of translational initiation	IDA IDA: Inferred from direct assay	32492408	GOA
involved in positive regulation of translational initiation	IDA IDA: Inferred from direct assay	28106076	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	32492408	GOA
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	32194978	GOA
involved in regulation of trophoblast cell migration	IMP IMP: Inferred from mutant phenotype	32194978	GOA
involved in stress granule assembly	IDA IDA: Inferred from direct assay	32451507	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	32492408	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	32492408	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	32451507	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDF3 Protein Structure

YTH

0
100
200
300
400
500
584 a.a.

Protein Preferred Names	Protein Names
YTH domain-containing family protein 3	YTH N(6)-methyladenosine RNA binding protein 3

YTHDF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	YTHDF3	Q7Z739	YTHDF1	Homo sapiens	Q9BYJ9	Anti Tag CoIP	28514442
Intra	YTHDF3	Q7Z739	YTHDF1	Homo sapiens	Q9BYJ9	Anti Tag CoIP	33961781
Intra	YTHDF3	Q7Z739	FAF1	Homo sapiens	Q9UNN5	Validated Y2H	32296183
Intra	YTHDF3	Q7Z739	FAF1	Homo sapiens	Q9UNN5	Y2H Array	32296183
Intra	YTHDF3	Q7Z739	FAF1	Homo sapiens	Q9UNN5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

YTHDF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811330	YTHDF3 Antibody	WB, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Retinitis Pigmentosa 11	RP11 Retinitis Pigmentosa-11 Retinitis Pigmentosa, Type 11
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176848	SKLB-Y13	Inhibitor	98.44%	Unkown
HY-168610	YTH-IN-1	Inhibitor	98.66%	Unkown
HY-RS15939	YTHDF3 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	YTHDF3	VGNC	VGNC:37043
Rattus norvegicus	YTHDF3	RGD	RGD:1305234
Macaca mulatta	YTHDF3	VGNC	VGNC:79614
Mus musculus	YTHDF3	MGD	MGI:1918850
Felis catus	YTHDF3	VGNC	VGNC:67153
Canis familiaris	YTHDF3	VGNC	VGNC:48507
Others	YTHDF3	NCBI