DT11-1
DT11-1 is a selective YTHDF2 inhibitor with an IC50 of 1.9 μM and a Kd of 34.6 μM. DT11-1 can be used for research on glioblastoma multiforme.
For research use only. We do not sell to patients.
- CAS No.: 59898-59-8
- Formula: C9H10N2OS2
- Molecular Weight:226.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
YTHDF2 1.9 μM (IC50) |
YTHDF1 24.9 μM (IC50) |
YTHDF3 44.9 μM (IC50) |
In Vitro
DT11-1 directly binds the YTHDF2 YTH domain with an MST Kd of 34.6 μM[1].
DT11-1 (30-45 μM; Day 2) shows no viability inhibition in HEK293T cells at 30 and 45 μM after 2 days[1].
DT11-1 (1-45 μM; 3 days) shows no toxicity in mouse primary cortical neurons at 45 μM after 3 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human LN229 glioblastoma cells
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Concentration:1, 7.5, 15, 30, and 45 μM
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Incubation Time:Day 1, Day 2, and Day 4
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Result:A similar reduction in LN229 viability signal required approximately 45 μM.
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Cell Line:Human HEK293T cells
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Concentration:30 and 45 μM
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Incubation Time:Day 2
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Result:At 2 days, at doses that produced notable LN229 viability inhibition, zero efficacy on HEK293T viability was observed.
Chemical Information
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CAS No. 59898-59-8
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Molecular Weight 226.33
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Formula C9H10N2OS2
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SMILES
CC1=C(SC2=C1C(N(C(N2)=S)C)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DT11-1 Related Classifications
HY-W164000 Related Classifications
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