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Glibenclamide potassium

(Synonyms: Glyburide potassium; Glybenclamide potassium)
29 Cited Publications
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Based on 29 publication(s) in Google Scholar

Glibenclamide (Glyburide) potassium is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide potassium inhibits P-glycoprotein. Glibenclamide potassium directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). Glibenclamide potassium interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. Glibenclamide potassium can induce autophagy.

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  • CAS No.: 52169-36-5
  • Formula: C23H27ClKN3O5S
  • Molecular Weight:532.09
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Glibenclamide potassium Chemical Structure
    Glibenclamide potassium Chemical Structure
  • Experimental Validation Results for Glibenclamide potassium
  • Experimental Validation Results for Glibenclamide potassium
  • Experimental Validation Results for Glibenclamide potassium
  • Experimental Validation Results for Glibenclamide potassium
  • Experimental Validation Results for Glibenclamide potassium
  • Experimental Validation Results for Glibenclamide potassium
CAS No.: 52169-36-5
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  • Glibenclamide potassium Chemical Structure
    Glibenclamide potassium Chemical Structure
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    Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]

    Customer Validation
     Immunoblots of DARTS assay that verified the binding of glyburide (50 µM, 24 h) to IFI16 in U251 cells (n = 3). An unpaired two-tailed t-test was applied. Data are presented as mean ± SD.

  • 1/16

    Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]

    Customer Validation
     Time response of the mice weight after implantation of U251R cells, on average, the xenograft was locally irradiated with 15 Gy of X-rays, and the mice were administered intragastrically with 1 mg/kg glyburide 2 h before irradiation (N = 5 per group). Data are presented as mean ± SD.

  • 1/16

    Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]

    Customer Validation
     Representative MRI images of U251R xenografts by T2-weighted MRI at 10-day and 20-day after cell implantation, the whole mount HE-stained brain sections of mice (administered intragastrically with 1 mg/kg glyburide 2 h before irradiation).

  • 1/16

    Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]

    Customer Validation
     Glyburide (administered intragastrically with 1 mg/kg glyburide 2 h before irradiation). The positive area of IFI16, HMOX1, and GPX4 in the U251R tumor tissues (N = 5 per group). An unpaired two-tailed t-test was applied. Data are presented as mean ± SD. “n” means the number of individual experiments. “N” represents the number of mice analyzed.

  • 1/16

    Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2020 Mar;153:104679. [Abstract]

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     Glucose-dependent insulinotropic effects of CPU025 in MIN6 cells. MIN6 cells were treated with 2 or 25 mM glucose in the absence or presence of Glibenclamide (3 μM).

  • 1/16

    Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2020 May 12:8:269. [Abstract]

    Customer Validation
     The inhibition of HSP70 releasing by Glibenclamide suppresses morphine-induced ER stress and the phosphorylation of PKA and NR-1. Glibenclamide (200 μM) inhibits the decrease of intracellular HSP70 caused by morphine in SH-SY5Y cells.

  • Glibenclamide potassium