Glibenclamide potassium
Based on 28 publication(s) in Google Scholar
Glibenclamide (Glyburide) potassium is a potassium salt of Glibenclamide (HY-15206). Glibenclamid potassium exists in anhydrous and hydrate forms, with higher solubility compared to pure Glibenclamide.
For research use only. We do not sell to patients.
- CAS No.: 52169-36-5
- Formula: C23H27ClKN3O5S
- Molecular Weight:532.09
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Glibenclamide potassium
More- Nat Metab. 2022 Feb;4(2):269-283. [Abstract]
- Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]
- Pharmacol Res. 2020 Mar;153:104679. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Int J Nanomedicine. 2025 Apr 5:20:4145-4163. [Abstract]
- Int J Biol Macromol. 2024 Sep 23;280(Pt 3):135876. [Abstract]
- Cell Rep. 2026 Jun 25;45(7):117613. [Abstract]
- Br J Pharmacol. 2020 May;177(10):2286-2302. [Abstract]
- Virulence. 2022 Dec;13(1):1486-1501. [Abstract]
- Pharmaceuticals (Basel). 2025 Sep 21;18(9):1420. [Abstract]
- Eur J Pharmacol. 2025 Aug 15:1001:177765. [Abstract]
- Int Immunopharmacol. 2024 Oct 27;143(Pt 2):113494. [Abstract]
- J Periodontal Res. 2022 Jun;57(3):448-460. [Abstract]
- Front Pharmacol. 2021 Apr 26:12:641829. [Abstract]
- BMC Biol. 2021 Mar 3;19(1):40. [Abstract]
- Front Cell Dev Biol. 2020 May 12:8:269. [Abstract]
- Cancers (Basel). 2023 Jun 3;15(11):3043. [Abstract]
- Front Physiol. 2021 Oct 28;12:770430. [Abstract]
- J Cell Physiol. 2024 Feb;239(2):e31117. [Abstract]
- Neurosci Res. 2024 Feb:199:21-29. [Abstract]
- Chin J Integr Med. 2022 Apr;28(4):319-329. [Abstract]
- PeerJ. 2023 May 25:11:e15407. [Abstract]
- Biomed Res Int. 2021 May 14:2021:5565748. [Abstract]
- eNeuro. 2022 Jul 19;9(4):ENEURO.0120-22.2022. [Abstract]
- Biopharm Drug Dispos. 2022 Dec;43(6):265-271. [Abstract]
- Res Sq. 2024 Sep 19.
- University of Colorado Denver. 2024.
- Research Square Preprint. 2020 Oct.
-
WB
-
In Vivo Efficacy Study
-
Histological Imaging/Staining
-
IHC
-
ELISA
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 52169-36-5
-
Molecular Weight 532.09
-
Formula C23H27ClKN3O5S
-
SMILES
O=C([N-]CCC1=CC=C(S(=O)(NC(NC2CCCCC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC.[K+]
-
Synonyms
Glyburide potassium
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (28)
-
Journal Impact Factor
-
Most Recent
-
Nat Metab
mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1. [Abstract]2022 Feb;4(2):269-283. PMID: 35228744 -
Nat Commun
Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma. [Abstract]2025 Jan 31;16(1):1212. PMID: 39890789
Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]
Immunoblots of DARTS assay that verified the binding of glyburide (50 µM, 24 h) to IFI16 in U251 cells (n = 3). An unpaired two-tailed t-test was applied. Data are presented as mean ± SD.
Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]
Time response of the mice weight after implantation of U251R cells, on average, the xenograft was locally irradiated with 15 Gy of X-rays, and the mice were administered intragastrically with 1 mg/kg glyburide 2 h before irradiation (N = 5 per group). Data are presented as mean ± SD.
Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]
Representative MRI images of U251R xenografts by T2-weighted MRI at 10-day and 20-day after cell implantation, the whole mount HE-stained brain sections of mice (administered intragastrically with 1 mg/kg glyburide 2 h before irradiation).
Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1212. [Abstract]
Glyburide (administered intragastrically with 1 mg/kg glyburide 2 h before irradiation). The positive area of IFI16, HMOX1, and GPX4 in the U251R tumor tissues (N = 5 per group). An unpaired two-tailed t-test was applied. Data are presented as mean ± SD. “n” means the number of individual experiments. “N” represents the number of mice analyzed.
-
Pharmacol Res
A novel FFA1 agonist, CPU025, improves glucose-lipid metabolism and alleviates fatty liver in obese-diabetic (ob/ob) mice. [Abstract]2020 Mar;153:104679. PMID: 32014571
Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2020 Mar;153:104679. [Abstract]
Glucose-dependent insulinotropic effects of CPU025 in MIN6 cells. MIN6 cells were treated with 2 or 25 mM glucose in the absence or presence of Glibenclamide (3 μM).
-
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Int J Nanomedicine
Electromechanical Regulation Underlying Protein Nanoparticle-Induced Osmotic Pressure in Neurotoxic Edema. [Abstract]2025 Apr 5:20:4145-4163. PMID: 40207308 -
Int J Biol Macromol
Duck hepatitis A virus 1-encoded 2B protein disturbs ion and organelle homeostasis to promote NF-κB/NLRP3-mediated inflammatory response. [Abstract]2024 Sep 23;280(Pt 3):135876. PMID: 39322136 -
Cell Rep
Type I unconventional protein secretion of the SARS-CoV-2 nucleocapsid protein promotes inflammatory cytokine release. [Abstract]2026 Jun 25;45(7):117613. PMID: 42360880 -
Br J Pharmacol
HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. [Abstract]2020 May;177(10):2286-2302. PMID: 31971610 -
Virulence
A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner. [Abstract]2022 Dec;13(1):1486-1501. PMID: 36040120 -
Pharmaceuticals (Basel)
2025 Sep 21;18(9):1420. PMID: 41011287 -
Eur J Pharmacol
Isoliensinine promotes vasorelaxation and inhibits constriction by regulating the calcium channel in hypertension: In vitro and in vivo approaches. [Abstract]2025 Aug 15:1001:177765. PMID: 40414594 -
Int Immunopharmacol
Nicorandil restores endothelial cell Kir6.2 expression to alleviate neuropathic pain in mice after chronic constriction injury. [Abstract]2024 Oct 27;143(Pt 2):113494. PMID: 39467345 -
J Periodontal Res
Study on the role of pyroptosis in bone resorption induced by occlusal trauma with or without periodontitis. [Abstract]2022 Jun;57(3):448-460. PMID: 35141913 -
Front Pharmacol
Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway. [Abstract]2021 Apr 26:12:641829. PMID: 33981226 -
BMC Biol
2021 Mar 3;19(1):40. PMID: 33658023 -
Front Cell Dev Biol
Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents. [Abstract]2020 May 12:8:269. PMID: 32500072
Glibenclamide potassium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2020 May 12:8:269. [Abstract]
The inhibition of HSP70 releasing by Glibenclamide suppresses morphine-induced ER stress and the phosphorylation of PKA and NR-1. Glibenclamide (200 μM) inhibits the decrease of intracellular HSP70 caused by morphine in SH-SY5Y cells.
-
Cancers (Basel)
SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters. [Abstract]2023 Jun 3;15(11):3043. PMID: 37297005 -
Front Physiol
Roles of Endothelial Motilin Receptor and Its Signal Transduction Pathway in Motilin-Induced Left Gastric Artery Relaxation in Dogs. [Abstract]2021 Oct 28;12:770430. PMID: 34777026 -
J Cell Physiol
Leptin excites basolateral amygdala principal neurons and reduces food intake by LepRb-JAK2-PI3K-dependent depression of GIRK channels. [Abstract]2024 Feb;239(2):e31117. PMID: 37683049 -
Neurosci Res
A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels. [Abstract]2024 Feb:199:21-29. PMID: 37442198 -
Chin J Integr Med
Pharmacodynamic Mechanism of Kuanxiong Aerosol for Vasodilation and Improvement of Myocardial Ischemia. [Abstract]2022 Apr;28(4):319-329. PMID: 34897591 -
PeerJ
PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery. [Abstract]2023 May 25:11:e15407. PMID: 37250720 -
Biomed Res Int
Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta. [Abstract]2021 May 14:2021:5565748. PMID: 34095301 -
eNeuro
PLCβ-Mediated Depletion of PIP2 and ATP-Sensitive K+ Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus. [Abstract]2022 Jul 19;9(4):ENEURO.0120-22.2022. PMID: 35788107 -
Biopharm Drug Dispos
Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells. [Abstract]2022 Dec;43(6):265-271. PMID: 36195987 -
-
-
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)