52169-36-5
Chemical Structure
Glibenclamide potassium
Synonym(s): Glyburide potassium; Glybenclamide potassium
- CAS No.: 52169-36-5
- Formula:C23H27ClKN3O5S
- Molecular Weight:532.09
IUPAC Name: potassium (5-chloro-2-methoxybenzoyl)(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)amide
InChIKey: KYWKCYNEBFMDBB-UHFFFAOYSA-M
SMILES: O=C([N-]CCC1=CC=C(S(=O)(NC(NC2CCCCC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC.[K+]
Biological Activity: Glibenclamide (Glyburide) potassium is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide potassium inhibits P-glycoprotein. Glibenclamide potassium directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide potassium interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide potassium can induce autophagy[5].
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Glibenclamide potassium | Glibenclamide (Glyburide) potassium is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide potassium inhibits P-glycoprotein. Glibenclamide potassium directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). Glibenclamide potassium interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. Glibenclamide potassium can induce autophagy. | |||||||||||||||||||||
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References
- [1]. Heo R, et al. The anti-diabetic drug trelagliptin induces vasodilation via activation of Kv channels and SERCA pumps. Life Sci. 2021;283:119868. [Content Brief]
- [3]. Golstein PE, et al. P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999;437(5):652-660. [Content Brief]
- [4]. Fernandes MA, et al. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. J Biochem Mol Toxicol. 2004;18(3):162-169. [Content Brief]
- [5]. Zhou J, et al. Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells. Int J Endocrinol. 2019;2019:1265175. [Content Brief]
