1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
    Autophagy
  2. Endogenous Metabolite
    Reactive Oxygen Species
    HIF/HIF Prolyl-Hydroxylase
    Autophagy
  3. Glucosamine

Glucosamine (Synonyms: D-Glucosamine; Chitosamine)

Cat. No.: HY-B1125 Purity: ≥98.0%
Handling Instructions

Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

For research use only. We do not sell to patients.

Glucosamine Chemical Structure

Glucosamine Chemical Structure

CAS No. : 3416-24-8

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100 mg USD 225 Ask For Quote & Lead Time

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Description

Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Glucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity[2].
Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3].
Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

179.17

Formula

C₆H₁₃NO₅

CAS No.
SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (558.13 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (18.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5813 mL 27.9065 mL 55.8129 mL
5 mM 1.1163 mL 5.5813 mL 11.1626 mL
10 mM 0.5581 mL 2.7906 mL 5.5813 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

GlucosamineD-Glucosamine ChitosamineEndogenous MetaboliteReactive Oxygen SpeciesHIF/HIF Prolyl-HydroxylaseAutophagyHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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Glucosamine
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HY-B1125
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