2. Metabolic Enzyme/Protease Others Immunology/Inflammation
  3. Endogenous Metabolite Drug Derivative Drug Isomer Interleukin Related
  4. N-Acetyl-D-glucosamine

N-Acetyl-D-glucosamine  (Synonyms: N-Acetyl-2-amino-2-deoxy-D-glucose)

Cat. No.: HY-A0132 Purity: 99.20%
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N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits.

For research use only. We do not sell to patients.

CAS No. : 7512-17-6

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N-Acetyl-D-glucosamine Related Antibodies

Top Publications Citing Use of Products
ELISA
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In Vivo Efficacy Study

    N-Acetyl-D-glucosamine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2023 Jun 22;20(1):146.  [Abstract]

    N-Acetyl-D-Glucosamine (GlcNAc) (20 μM; 72 h) replenishment significantly increased UDP-GlcNAc level of cKO astrocytes.

    N-Acetyl-D-glucosamine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2023 Jun 22;20(1):146.  [Abstract]

    N-Acetyl-D-Glucosamine (GlcNAc) (20 μM; 72 h) supplementation reduced the staining intensity of GFAP and IL-1β of the cultured cKO astrocytes.

    N-Acetyl-D-glucosamine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2023 Jun 22;20(1):146.  [Abstract]

    N-Acetyl-D-Glucosamine (GlcNAc) (20 μM; 72 h) supplementation significantly restored the decreased level of O-GlcNAcylation, and reduced the levels of GFAP, IL-1β and TNF-α of cKO astrocytes in vitro.

    N-Acetyl-D-glucosamine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2023 Jun 22;20(1):146.  [Abstract]

    Y maze spontaneous alternation task test results showed that N-Acetyl-D-Glucosamine (GlcNAc) (400 mg/kg; i.p.; once daily for 14 d) increased the percentage of spontaneous alternations of cKO mice.

    N-Acetyl-D-glucosamine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2023 Jun 22;20(1):146.  [Abstract]

    N-Acetyl-D-Glucosamine (GlcNAc) (400 mg/kg; i.p.; once daily for 14 d) supplementation significantly increased the immunostaining intensity of O-GlcNAcylation in the brain of cKO mice.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    IL-6

     

    IL-1β

     

    In Vitro

    N-Acetyl-D-Glucosamine inhibits IL-1β and TNFα production and induces NO, cycloox-ygenase-2 and IL-6 production in normal human articular chondrocytes[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    N-Acetyl-D-glucosamine Related Antibodies
    In Vivo

    N-Acetyl-D-Glucosamine (1, 2, or 4% (w/w), mixed in powdered diet, daily for 28 days before transplantation of the tumor cells and daily for 14 days after transplantation of the tumor cells) suppresses tumor growth in mouse or rat tumor models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mouse or rat tumor models[2]
    Dosage: 1, 2, or 4% (w/w)
    Administration: mixed in powdered diet, daily for 28 days before transplantation of the tumor cells and daily for 14 days after transplantation of the tumor cells
    Result: Significantly lowered the tumor volumes calculated in the NACOS 2% (369.8±74.0 mm3), NACOS 4% (307.5±107.0 mm3) and significantly increased serum IFN-γ and IL-12p70 levels.
    Clinical Trial
    Molecular Weight

    221.21

    Formula

    C8H15NO6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C[C@@H]([C@@H](O)[C@H](O)[C@H](O)CO)NC(C)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (565.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 100 mg/mL (452.06 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.5206 mL 22.6030 mL 45.2059 mL
    5 mM 0.9041 mL 4.5206 mL 9.0412 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

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    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 3.25 mg/mL (14.69 mM); Clear solution

      This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 3.25 mg/mL (14.69 mM); Clear solution

      This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (226.03 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.5%

    SDS (394 KB)

    COA (248 KB) HNMR (116 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 4.5206 mL 22.6030 mL 45.2059 mL 113.0148 mL
    5 mM 0.9041 mL 4.5206 mL 9.0412 mL 22.6030 mL
    10 mM 0.4521 mL 2.2603 mL 4.5206 mL 11.3015 mL
    15 mM 0.3014 mL 1.5069 mL 3.0137 mL 7.5343 mL
    20 mM 0.2260 mL 1.1301 mL 2.2603 mL 5.6507 mL
    25 mM 0.1808 mL 0.9041 mL 1.8082 mL 4.5206 mL
    30 mM 0.1507 mL 0.7534 mL 1.5069 mL 3.7672 mL
    40 mM 0.1130 mL 0.5651 mL 1.1301 mL 2.8254 mL
    50 mM 0.0904 mL 0.4521 mL 0.9041 mL 2.2603 mL
    60 mM 0.0753 mL 0.3767 mL 0.7534 mL 1.8836 mL
    80 mM 0.0565 mL 0.2825 mL 0.5651 mL 1.4127 mL
    100 mM 0.0452 mL 0.2260 mL 0.4521 mL 1.1301 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    N-Acetyl-D-glucosamine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    N-Acetyl-D-glucosamine7512-17-6N-Acetyl-2-amino-2-deoxy-D-glucoseEndogenous MetaboliteDrug DerivativeDrug IsomerInterleukin RelatedDrug derivativeILN-acetylglucosamineorally activebacterial metabolitecartilaginous injuriesInhibitorinhibitorinhibit

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