1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. D-Galactose

D-Galactose (Synonyms: D-(+)-Galactose)

Cat. No.: HY-N0210 Purity: >98.0%
Handling Instructions

D-Galactose is a natural aldohexose and C-4 epimer of glucose.

For research use only. We do not sell to patients.

D-Galactose Chemical Structure

D-Galactose Chemical Structure

CAS No. : 59-23-4

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10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 84 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

D-Galactose is a natural aldohexose and C-4 epimer of glucose.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Galactose is important for the survival and virulence of bacteria. In Escherichia coli galactose is utilized by the Leloir pathway. Two anomers of d-galactose are used for different purposes, α-d-galactose as a carbon source and β-d-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylation[1].

In Vivo

Chronic D-galactose exposure induces neurodegeneration by enhancing caspase-mediated apoptosis and inhibiting neurogenesis and neuron migration in mice, as well as increasing oxidative damage. In addition, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents[2]. D-galactose given by oral route causes cognitive impairments in rats which are accompanied by oxidative damage. Cognitive impairments is observed in the open-field test in the 4th and 6th weeks after d-gal administration, as well as an impairment in spatial memory in the radial maze test after the 6th week of d-gal administration[3].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (555.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5506 mL 27.7531 mL 55.5062 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL
10 mM 0.5551 mL 2.7753 mL 5.5506 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2][3]

Rats: D-galactose is dissolved in water for administration at the dose of 100 mg/kg of body weight, and given by oral gavage, once a day, over a period of 1, 2, 4, 6 or 8 weeks. Animals are randomized into two groups: control animals (receiving water by oral gavage) or d-gal animals (receiving D-galactose by oral gavage). The behavioral tests and biochemical analysis are undertaken on the1st, 2nd, 4th, 6th and 8th weeks after the last administration of d-gal[3].

Mice: Male adult C57BL/6 mice are randomly divided into three groups (control, D-galactose, and D-galactose plus α-LA). D-galactose (100 mg/kg) is injected subcutaneously (s.c.) daily into mice for 7 weeks. α-LA (100 mg/kg body weight) is injected peritoneally (i.p.) daily concomitantly for 7 weeks. All control animals are given saline[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

180.16

Formula

C₆H₁₂O₆

CAS No.

59-23-4

SMILES
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Room temperature in continental US; may vary elsewhere

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D-Galactose
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D-Galactose

Cat. No.: HY-N0210