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  4. D-Glucose

D-Glucose  (Synonyms: Glucose; D-(+)-Glucose; Dextrose)

Cat. No.: HY-B0389 Purity: 98.0%
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SDS
Handling Instructions Technical Support

D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response.

For research use only. We do not sell to patients.

CAS No. : 50-99-7

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Customer Review

Based on 53 publication(s) in Google Scholar

Other Forms of D-Glucose:

D-Glucose Related Antibodies

Top Publications Citing Use of Products

53 Publications Citing Use of MCE D-Glucose

Apoptosis Analysis
WB
IF

    D-Glucose purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Feb 4;23(1):81.  [Abstract]

    Human podocyte fibrosis and inflammatory factor secretion were significantly higher in patients treated with HG (30 mM glucose for 24 h)+AGEs than in those treated with fTAC alone.

    D-Glucose purchased from MedChemExpress. Usage Cited in: ACS Nano. 2023 Sep 26;17(18):18037-18054.  [Abstract]

    Relative cell viability of human kidney podocyte after coincubation with HG (containing 25 mM of glucose (24 h)), HHG (containing 75 mM of glucose (24 h)) and various components of ESC-HCM-B.

    D-Glucose purchased from MedChemExpress. Usage Cited in: ACS Nano. 2023 Sep 26;17(18):18037-18054.  [Abstract]

    The mitochondrial membrane potential of human kidney podocyte after coincubation with HG (containing 25 mM of glucose (24 h)), HHG (containing 75 mM of glucose 24 h) and various components of ESC-HCM-B, the scale bar = 100 μm.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response[1][2][3].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    D-Glucose (25-150 mM, 20min) increases the release of 5-Hydroxytryptamine from human BON cells dose-dependently[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    D-Glucose Related Antibodies
    In Vivo

    D-Glucose (250, 500, 750 mg/kg, i.v., acute administration) protects rats' isletβcells from Alloxan induced diabetes[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male rats (Charles River strain) with alloxan induced diabetes[2]
    Dosage: 250, 500, 750 mg/kg
    Administration: Intravenous injection (i.v.)
    Result: Demonstrated slight to moderate degranulation of isletβcells and only minimal or absent evidence of injury, while β cell necrosis was noted in those receiving only alloxan.
    Clinical Trial
    Molecular Weight

    180.16

    Formula

    C6H12O6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 50 mg/mL (277.53 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.5506 mL 27.7531 mL 55.5062 mL
    5 mM 1.1101 mL 5.5506 mL 11.1012 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (555.06 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.81%

    SDS (396 KB)

    COA (248 KB) HNMR (115 KB) RP-HPLC (230 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.5506 mL 27.7531 mL 55.5062 mL 138.7655 mL
    5 mM 1.1101 mL 5.5506 mL 11.1012 mL 27.7531 mL
    10 mM 0.5551 mL 2.7753 mL 5.5506 mL 13.8766 mL
    15 mM 0.3700 mL 1.8502 mL 3.7004 mL 9.2510 mL
    20 mM 0.2775 mL 1.3877 mL 2.7753 mL 6.9383 mL
    25 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
    30 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6255 mL
    40 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4691 mL
    50 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
    60 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
    80 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
    100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    D-Glucose Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    D-Glucose50-99-7Glucose D-(+)-Glucose DextroseEnvironmental PollutantsEndogenous MetaboliteEnvironmental Contaminantsmonosaccharidegeneral metabolismstress responsehBONInhibitorinhibitorinhibit

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