D-Glucose-13C6
Based on 18 publication(s) in Google Scholar
D-Glucose-13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose-13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 110187-42-3
- Formula: 13C6H12O6
- Molecular Weight:186.11
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) D-Glucose-13C6
More- Cell Stem Cell. 2023 Aug 3;30(8):1028-1042.e7. [Abstract]
- Cancer Res. 2025 Sep 3. [Abstract]
- Nat Commun. 2026 Mar 3;17(1):3382. [Abstract]
- Nat Commun. 2025 May 15;16(1):4502. [Abstract]
- Nat Commun. 2024 Aug 22;15(1):7241. [Abstract]
- Neuron. 2025 Jun 4;113(11):1708-1722.e5. [Abstract]
- Adv Sci (Weinh). 2022 Oct 28;e2204711. [Abstract]
- Nat Struct Mol Biol. 2024 May 20. [Abstract]
- Food Chem. 2025 Nov 15;492(Pt 3):145522. [Abstract]
- J Colloid Interface Sci. 2025 Dec 3:706:139625. [Abstract]
- Proc Natl Acad Sci U S A. 2026 Jul 7;123(27):e2523789123.
- J Transl Med. 2023 Dec 4;21(1):877. [Abstract]
- Cancer Metab. 2025 Aug 14;13(1):37. [Abstract]
- Int J Mol Sci. 2025 Nov 27;26(23):11475. [Abstract]
- Cancers (Basel). 2026 Jun 16;18(12):1953. [Abstract]
- Immunotargets Ther. 2025 Oct 22:14:1145-1158. [Abstract]
- Res Sq. 2026 Jan 12.
- bioRxiv. 2024 August 10.
Customer Validation & Images
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Bio/Physico-chemical Assay
All Endogenous Metabolite Isoforms
More
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ceratitis capitata [1]
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Dosage:0.1 g
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Administration:Add into 25 g carrot medium for eggs or incorporated with 1 g of 99.5% sucrose in 15 mL water for adults
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Result:Decreased hatching rate from 85% to 79% and number of emerged adults from 57% to 50.6%, prolonged development time.
Decreased the number and period of mating lightly for larvae labeled flies, while decreased the period of mating a bit more for adult labeled flies.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 110187-42-3
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Unlabeled Cas 50-99-7
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Appearance Solid
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Molecular Weight 186.11
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Formula 13C6H12O6
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Color White to off-white
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SMILES
O=[13CH][13C@@H]([13C@H]([13C@@H]([13C@@H]([13CH2]O)O)O)O)O
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Synonyms
Glucose-13C6; D-(+)-Glucose-13C6; Dextrose-13C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (18)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration. [Abstract]2023 Aug 3;30(8):1028-1042.e7. PMID: 37541209
D-Glucose-13C6 purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2023 Aug 3;30(8):1028-1042.e7. [Abstract]
Heatmap of sum of abundance of all 13C-labeled glycolytic intermediates and TCA cycle intermediates in 3-mo and 12-mo AT2 cells after [U-13C]-glucose infusion (n = 3 per group).
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Cancer Res
A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression. [Abstract]2025 Sep 3. PMID: 40900036 -
Nat Commun
TIGAR regulates intestinal mucus barrier integrity by inhibiting lactylation of G6PD/6PGD in ulcerative colitis. [Abstract]2026 Mar 3;17(1):3382. PMID: 41776188 -
Nat Commun
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis. [Abstract]2025 May 15;16(1):4502. PMID: 40374622 -
Nat Commun
Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation. [Abstract]2024 Aug 22;15(1):7241. PMID: 39174557 -
Neuron
Comprehensive characterization of metabolic consumption and production by the human brain. [Abstract]2025 Jun 4;113(11):1708-1722.e5. PMID: 40147438 -
Adv Sci (Weinh)
Upregulation of Superenhancer-Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma. [Abstract]2022 Oct 28;e2204711. PMID: 36307901 -
Nat Struct Mol Biol
RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth. [Abstract]2024 May 20. PMID: 38769389 -
Food Chem
Evaluation of intermediate compounds in β-carboline alkaloids formation using model system including isotope labeled glycerol. [Abstract]2025 Nov 15;492(Pt 3):145522. PMID: 40701085 -
J Colloid Interface Sci
Dual-functional copper nanoplatform potentiates cuproptosis through p53 reactivation and metabolic reprogramming. [Abstract]2025 Dec 3:706:139625. PMID: 41352051 -
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J Transl Med
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003. [Abstract]2023 Dec 4;21(1):877. PMID: 38049827 -
Cancer Metab
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming. [Abstract]2025 Aug 14;13(1):37. PMID: 40814066 -
Int J Mol Sci
Melatonin Rescues Heat Stress-Induced Suppression of TCA Cycle and Mitochondrial Damage in Goat Sertoli Cells. [Abstract]2025 Nov 27;26(23):11475. PMID: 41373630 -
Cancers (Basel)
Transcription Factor ATF4 Deletion Reprograms Glucose Metabolism in Clear Cell Renal Cell Carcinoma. [Abstract]2026 Jun 16;18(12):1953. PMID: 42352488 -
Immunotargets Ther
2025 Oct 22:14:1145-1158. PMID: 41146849 -
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Solvent & Solubility
H2O : 100 mg/mL (537.32 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (537.32 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[2]. Malz F, et al. Synthesis of methyl 4'-O-methyl-beta-D-cellobioside-13C12 from D-glucose-13C6. Part 2: solid-state NMR studies. Carbohydr Res. 2007 Jan 15;342(1):65-70. [Content Brief]
[3]. Zhang H, et al. A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6]glucose as a tracer. Clin Chem. 2009 Mar;55(3):527-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3732 mL | 26.8658 mL | 53.7317 mL | 134.3292 mL |
| 5 mM | 1.0746 mL | 5.3732 mL | 10.7463 mL | 26.8658 mL | |
| 10 mM | 0.5373 mL | 2.6866 mL | 5.3732 mL | 13.4329 mL | |
| 15 mM | 0.3582 mL | 1.7911 mL | 3.5821 mL | 8.9553 mL | |
| 20 mM | 0.2687 mL | 1.3433 mL | 2.6866 mL | 6.7165 mL | |
| 25 mM | 0.2149 mL | 1.0746 mL | 2.1493 mL | 5.3732 mL | |
| 30 mM | 0.1791 mL | 0.8955 mL | 1.7911 mL | 4.4776 mL | |
| 40 mM | 0.1343 mL | 0.6716 mL | 1.3433 mL | 3.3582 mL | |
| 50 mM | 0.1075 mL | 0.5373 mL | 1.0746 mL | 2.6866 mL | |
| 60 mM | 0.0896 mL | 0.4478 mL | 0.8955 mL | 2.2388 mL | |
| 80 mM | 0.0672 mL | 0.3358 mL | 0.6716 mL | 1.6791 mL | |
| 100 mM | 0.0537 mL | 0.2687 mL | 0.5373 mL | 1.3433 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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