Beta cell protection to alloxan necrosis by anomers of D-glucose

  • Science. 1974 Feb 1;183(4123):424. doi: 10.1126/science.183.4123.424.
A A Rossini ,  M Berger ,  J Shadden ,  G F Cahill Jr
PMID: 4587675 DOI: 10.1126/science.183.4123.424
Abstract

Various concentrations of either the alpha or beta anomers of D-glucose were injected into fasted rats prior to a diabetogenic dose of alloxan. Plasma concentrations of glucose were measured 24 hours later. There was a significantly greater protection of the pancreatic beta cells by the alpha anomer of D-glucose as compared to the beta anomer, which was evidenced by concentrations of glucose in the plasma, and morphology of beta cells.

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