2. NF-κB Immunology/Inflammation Metabolic Enzyme/Protease Autophagy
  3. Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy
  4. Glucosamine sulfate

Glucosamine sulfate  (Synonyms: D-Glucosamine sulfate)

Cat. No.: HY-N0487 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

For research use only. We do not sell to patients.

CAS No. : 29031-19-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
500 mg In-stock
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5 g In-stock
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Glucosamine sulfate:

Glucosamine sulfate Related Antibodies

Top Publications Citing Use of Products

    Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674.  [Abstract]

    LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). Cell death was measured after treatment for 24 h.

    Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674.  [Abstract]

    LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). MDA was measured after treatment for 16 h.

    Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674.  [Abstract]

    Metabolites downstream of GFPT1 restore YAP alteration by erastin. p-YAPS127, O-YAPT241 and YAP were measured by IB in H1975 cells treated with or without erastin, glucose, GlcN (5 mM) or GlcNAc for 8 h.

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    Human Endogenous Metabolite Microbial Metabolite

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    HIF-1α HIF

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

    IC50 & Target[1]

    Human Endogenous Metabolite

     

    In Vitro

    Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity[2].
    Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3].
    Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Glucosamine sulfate Related Antibodies
    Molecular Weight

    277.25

    Formula

    C6H15NO9S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.O=S(O)(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 125 mg/mL (450.86 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6069 mL 18.0343 mL 36.0685 mL
    5 mM 0.7214 mL 3.6069 mL 7.2137 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (360.69 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (394 KB)

    COA (254 KB) HNMR (277 KB) MS (70 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.6069 mL 18.0343 mL 36.0685 mL 90.1713 mL
    5 mM 0.7214 mL 3.6069 mL 7.2137 mL 18.0343 mL
    10 mM 0.3607 mL 1.8034 mL 3.6069 mL 9.0171 mL
    15 mM 0.2405 mL 1.2023 mL 2.4046 mL 6.0114 mL
    20 mM 0.1803 mL 0.9017 mL 1.8034 mL 4.5086 mL
    25 mM 0.1443 mL 0.7214 mL 1.4427 mL 3.6069 mL
    30 mM 0.1202 mL 0.6011 mL 1.2023 mL 3.0057 mL
    40 mM 0.0902 mL 0.4509 mL 0.9017 mL 2.2543 mL
    50 mM 0.0721 mL 0.3607 mL 0.7214 mL 1.8034 mL
    60 mM 0.0601 mL 0.3006 mL 0.6011 mL 1.5029 mL
    80 mM 0.0451 mL 0.2254 mL 0.4509 mL 1.1271 mL
    100 mM 0.0361 mL 0.1803 mL 0.3607 mL 0.9017 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Glucosamine sulfate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Glucosamine29031-19-4D-GlucosamineEndogenous MetaboliteReactive Oxygen Species (ROS)HIF/HIF Prolyl-HydroxylaseAutophagyHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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