Glucosamine sulfate
Based on 12 publication(s) in Google Scholar
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 29031-19-4
- Formula: C6H15NO9S
- Molecular Weight:277.25
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications Citing Use of MedChemExpress (MCE) Glucosamine sulfate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mil Med Res. 2025 Jul 28;12(1):39. [Abstract]
- Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]
- Microbiome. 2019 Mar 20;7(1):43. [Abstract]
- Cell Rep. 2025 Sep 10;44(9):116249. [Abstract]
- Int Immunopharmacol. 2024 Oct 18;143(Pt 2):113427. [Abstract]
- Artif Cells Nanomed Biotechnol. 2026 Dec;54(1):248-275. [Abstract]
- Am J Physiol Gastrointest Liver Physiol. 2025 Jun 1;328(6):G746-G759. [Abstract]
- Diabetes Metab Syndr Obes. 2025 Jul 29:18:2573-2584. [Abstract]
- Biocell. 2025 Sep 25;49(9):1711-1731.
- bioRxiv. 2026 Jan 26.
- Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
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WB
All Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity[2].
Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3].
Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 29031-19-4
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Appearance Solid
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Molecular Weight 277.25
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Formula C6H15NO9S
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Color White to off-white
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SMILES
O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.O=S(O)(O)=O
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Synonyms
D-Glucosamine sulfate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mil Med Res
Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids. [Abstract]2025 Jul 28;12(1):39. PMID: 40722047 -
Theranostics
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. [Abstract]2021 Mar 24;11(12):5650-5674. PMID: 33897873
Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]
LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). Cell death was measured after treatment for 24 h.
Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]
LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). MDA was measured after treatment for 16 h.
Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]
Metabolites downstream of GFPT1 restore YAP alteration by erastin. p-YAPS127, O-YAPT241 and YAP were measured by IB in H1975 cells treated with or without erastin, glucose, GlcN (5 mM) or GlcNAc for 8 h.
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Microbiome
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]2019 Mar 20;7(1):43. PMID: 30890187 -
Cell Rep
The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level. [Abstract]2025 Sep 10;44(9):116249. PMID: 40938752 -
Int Immunopharmacol
2024 Oct 18;143(Pt 2):113427. PMID: 39426230 -
Artif Cells Nanomed Biotechnol
Characterization of genipin-crosslinked gelatin/PVA hydrogels and the chondroprotective influence of hydroxytyrosol: an In vitro study. [Abstract]2026 Dec;54(1):248-275. PMID: 42331338 -
Am J Physiol Gastrointest Liver Physiol
Glucose metabolism through the hexosamine biosynthetic pathway drives hepatic de novo lipogenesis via promoting N-linked protein glycosylation. [Abstract]2025 Jun 1;328(6):G746-G759. PMID: 40331866 -
Diabetes Metab Syndr Obes
2025 Jul 29:18:2573-2584. PMID: 40755745 -
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Solvent & Solubility
H2O : 125 mg/mL (450.86 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (360.69 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7. [Content Brief]
[2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9. [Content Brief]
[3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706. [Content Brief]
[4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.6069 mL | 18.0343 mL | 36.0685 mL | 90.1713 mL |
| 5 mM | 0.7214 mL | 3.6069 mL | 7.2137 mL | 18.0343 mL | |
| 10 mM | 0.3607 mL | 1.8034 mL | 3.6069 mL | 9.0171 mL | |
| 15 mM | 0.2405 mL | 1.2023 mL | 2.4046 mL | 6.0114 mL | |
| 20 mM | 0.1803 mL | 0.9017 mL | 1.8034 mL | 4.5086 mL | |
| 25 mM | 0.1443 mL | 0.7214 mL | 1.4427 mL | 3.6069 mL | |
| 30 mM | 0.1202 mL | 0.6011 mL | 1.2023 mL | 3.0057 mL | |
| 40 mM | 0.0902 mL | 0.4509 mL | 0.9017 mL | 2.2543 mL | |
| 50 mM | 0.0721 mL | 0.3607 mL | 0.7214 mL | 1.8034 mL | |
| 60 mM | 0.0601 mL | 0.3006 mL | 0.6011 mL | 1.5029 mL | |
| 80 mM | 0.0451 mL | 0.2254 mL | 0.4509 mL | 1.1271 mL | |
| 100 mM | 0.0361 mL | 0.1803 mL | 0.3607 mL | 0.9017 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.