2. Membrane Transporter/Ion Channel Cell Cycle/DNA Damage
  3. CFTR Deubiquitinase
  4. MS6178

MS6178 is a MS5105-based CFTR deubiquitinase-targeted chimera (DUBTAC) that recruits OTUB1 to stabilize ΔF508-CFTR mutant protein in a concentration- and time-dependent manner, with an OTUB1-dependent effect and no impact on CFTR mRNA level. MS6178 can be used for the research of cancer.

For research use only. We do not sell to patients.

MS6178

MS6178 Chemical Structure

CAS No. : 3060520-53-5

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MS6178 Related Antibodies

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Description

MS6178 is a MS5105-based CFTR deubiquitinase-targeted chimera (DUBTAC) that recruits OTUB1 to stabilize ΔF508-CFTR mutant protein in a concentration- and time-dependent manner, with an OTUB1-dependent effect and no impact on CFTR mRNA level. MS6178 can be used for the research of cancer[1].

In Vitro

MS6178 (0.5-10 µM; 0-24 h) effectively stabilizes the ΔF508-CFTR mutant protein in CFBE41o-4.7 ΔF508-CFTR cells in a concentration-, time-, OTUB1-, and CFTR-dependent manner (30-fold increase at 10 μM for 24 h)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS6178 Related Antibodies
Molecular Weight

898.03

Formula

C47H53F2N7O7S
CAS No.
SMILES

O=C(NC1=NC(C2=CC=CC(C(NCCCCCCC(NCCC3=CC=C(N4CCN(C(/C=C/CN(C)C)=O)CC4=O)S3)=O)=O)=C2)=C(C)C=C1)C5(CC5)C6=CC7=C(OC(F)(F)O7)C=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MS6178 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS61783060520-53-5MS 6178MS-6178CFTRDeubiquitinaseCystic fibrosis transmembrane conductance regulatorDUBsΔF508-CFTR mutant proteinDUBTACCFBE41o-4.7 ΔF508-CFTR cellsOTUB1CFTR mRNANJH-2-057Inhibitorinhibitorinhibit

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