2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Elastase CFTR
  4. Neltenexine

Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research.

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Neltenexine

Neltenexine Chemical Structure

CAS No. : 99453-84-6

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Description

Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research[1][2].

Molecular Weight

488.24

Formula

C18H20Br2N2O2S
CAS No.
SMILES

O=C(C1=CC=CS1)NC2=C(C=C(C=C2Br)Br)CN[C@H]3CC[C@@H](CC3)O
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Purity & Documentation
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Neltenexine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neltenexine99453-84-6ElastaseCFTRCystic fibrosis transmembrane conductance regulatorCOPDAnion secretionInhibitorinhibitorinhibit

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