99453-84-6
Chemical Structure
Neltenexine
- CAS No.: 99453-84-6
- Formula:C18H20Br2N2O2S
- Molecular Weight:488.24
InChIKey: SSLHKNBKUBAHJY-HDJSIYSDSA-N
SMILES: O=C(C1=CC=CS1)NC2=C(C=C(C=C2Br)Br)CN[C@H]3CC[C@@H](CC3)O
Biological Activity: Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research[1][2].
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Neltenexine | Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research. | |||||||||||||||||||||
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- [1]. Braga PC, et al. Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats. Drugs Exp Clin Res. 1995;21(2):51-7. [Content Brief]
- [2]. Niisato N, et al. Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun. 2007 May 18;356(4):1050-5. [Content Brief]
Keywords
