99453-84-6
Chemical Structure
Neltenexine
- CAS No.: 99453-84-6
- Formula:C18H20Br2N2O2S
- Molecular Weight:488.24
InChIKey: SSLHKNBKUBAHJY-HDJSIYSDSA-N
SMILES: O=C(C1=CC=CS1)NC2=C(C=C(C=C2Br)Br)CN[C@H]3CC[C@@H](CC3)O
Biological Activity: Neltenexine is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells. Neltenexine reduces Cl-/HCO3- uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl- excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels. Neltenexine can be used in research related to chronic obstructive pulmonary disease and emphysema[1][2].
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Neltenexine | Neltenexine is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells. Neltenexine reduces Cl-/HCO3- uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl- excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels. Neltenexine can be used in research related to chronic obstructive pulmonary disease and emphysema. | |||||||||||||||||||||
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- [1]. Niisato N, et al. Action of neltenexine on anion secretion in human airway epithelia. Biochemical and biophysical research communications. 2007 May 18;356(4):1050-5. [Content Brief]
- [2]. Braga PC, et al. Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats. Drugs under experimental and clinical research. 1995;21(2):51-7. [Content Brief]
Keywords
