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GGA1 - golgi associated, gamma adaptin ear containing, ARF binding protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26088

About GGA1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,608,834-37,633,564 (from NCBI)

This gene has 23 transcripts (splice variants), 273 orthologues and 10 paralogues. Broad expression in testis (RPKM 36.8), spleen (RPKM 8.3) and 23 other tissues.

Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GGA1 Products (5)

mRNA	Protein	Name
NM_001001560.3	NP_001001560.1	ADP-ribosylation factor-binding protein GGA1 isoform 2
NM_001172687.2	NP_001166158.1	ADP-ribosylation factor-binding protein GGA1 isoform 4
NM_001172688.2	NP_001166159.1	ADP-ribosylation factor-binding protein GGA1 isoform 5
NM_001363771.2	NP_001350700.1	ADP-ribosylation factor-binding protein GGA1 isoform 6
NM_013365.5	NP_037497.1	ADP-ribosylation factor-binding protein GGA1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11387475	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	12668765	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	27901063	GOA
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	15886016	GOA
involved in protein localization	IDA IDA: Inferred from direct assay	15886016	GOA
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	27901063	GOA
involved in retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	15886016	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	15886016	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	12668765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGA1 Protein Structure

VHS

GAT

Alpha_adaptinC2

0
100
200
300
400
500
600
639 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-binding protein GGA1	ADP-ribosylation factor binding protein 1

GGA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GGA1	Q9UJY5	IGF2R	Homo sapiens	P11717	Pull Down	11387475
Intra	GGA1	Q9UJY5	IGF2R	Homo sapiens	P11717	Y2H	11387475
Intra	GGA1	Q9UJY5	IGF2R	Homo sapiens	P11717	FPS	37219487
Intra	GGA1	Q9UJY5	SORT1	Homo sapiens	Q99523	Far-WB	20676133
Intra	GGA1	Q9UJY5	SORL1	Homo sapiens	Q92673	Pull Down	11821067
Intra	GGA1	Q9UJY5	BACE1	Homo sapiens	P56817	Anti Tag CoIP	26053850
Intra	GGA1	Q9UJY5	GTSE1	Homo sapiens	Q9NYZ3	FPS	37219487
Intra	GGA1	Q9UJY5	GTSE1	Homo sapiens	Q9NYZ3	Phage Display	37219487
Intra	GGA1	Q9UJY5	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	GGA1	Q9UJY5	MYH9	Homo sapiens	P35579	Phage Display	39009827
Intra	GGA1	Q9UJY5	MYH9	Homo sapiens	P35579	FPS	39009827
Intra	GGA1	Q9UJY5	MON2	Homo sapiens	Q7Z3U7	Anti Tag CoIP	18418388
Intra	GGA1	Q9UJY5	MON2	Homo sapiens	Q7Z3U7	Pull Down	18418388
Intra	GGA1	Q9UJY5	RNF11	Homo sapiens	Q9Y3C5	Y2H	15231748
Intra	GGA1	Q9UJY5	RNF11	Homo sapiens	Q9Y3C5	FPS	37219487
Intra	GGA1	Q9UJY5	RNF11	Homo sapiens	Q9Y3C5	Phage Display	37219487
Intra	GGA1	Q9UJY5	RNF11	Homo sapiens	Q9Y3C5	ITC	37219487
Intra	GGA1	Q9UJY5	RNF11	Homo sapiens	Q9Y3C5	Far-WB	20676133
Intra	GGA1	Q9UJY5	RABEP1	Homo sapiens	Q15276	Anti Tag CoIP	12505986
Intra	GGA1	Q9UJY5	RABEP1	Homo sapiens	Q15276	X-Ray Diffraction	14637142
Intra	GGA1	Q9UJY5	RABEP1	Homo sapiens	Q15276	Y2H	12505986
Intra	GGA1	Q9UJY5	GGA3	Homo sapiens	Q9NZ52	Pull Down	14638859
Intra	GGA1	Q9UJY5	GGA3	Homo sapiens	Q9NZ52	EM	14638859
Intra	GGA1	Q9UJY5	GGA2	Homo sapiens	Q9UJY4	EM	14638859
Intra	GGA1	Q9UJY5	GGA2	Homo sapiens	Q9UJY4	Pull Down	14638859
Intra	GGA1	Q9UJY5	GGA2	Homo sapiens	Q9UJY4	Confocal	14638859
Intra	GGA1	Q9UJY5	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956
Intra	GGA1	Q9UJY5	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	25416956
Intra	GGA1	Q9UJY5	C1orf216	Homo sapiens	Q8TAB5	Y2H Array	25416956
Intra	GGA1	Q9UJY5	JUN	Homo sapiens	P05412	Phage Display	37219487
Intra	GGA1	Q9UJY5	JUN	Homo sapiens	P05412	FPS	37219487
Cross	GGA1	Q9UJY5	RABGEF1	Bos taurus	O18973	Immunodepletion CoIP	12505986

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05393	GGA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GGA1	VGNC	VGNC:29335
Macaca mulatta	GGA1	VGNC	VGNC:72737
Canis familiaris	GGA1	VGNC	VGNC:41193
Rattus norvegicus	GGA1	RGD	RGD:1307770
Mus musculus	GGA1	MGD	MGI:2146207
Others	GGA1	NCBI