USP19 - ubiquitin specific peptidase 19 Gene
Also Known as ZMYND9
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 10869
About USP19
Cytogenetic location: 3p21.31
Genomic coordinates (GRCh38): 3:49,108,050-49,120,823 (from NCBI)
This gene has 14 transcripts (splice variants), 202 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 12.9), thyroid (RPKM 11.3) and 25 other tissues.
Summary
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating Enzymes and deubiquitinating Enzymes, adds and removes ubiquitin. Deubiquitinating Enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein Ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
USP19 Products (40)
| mRNA | Protein | Name |
|---|---|---|
| NM_001199160.2 | NP_001186089.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 1 |
| NM_001199161.2 | NP_001186090.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 2 |
| NM_001199162.2 | NP_001186091.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 3 |
| NM_001351098.2 | NP_001338027.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 5 |
| NM_001351099.2 | NP_001338028.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 6 |
| NM_001351100.2 | NP_001338029.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 7 |
| NM_001351101.2 | NP_001338030.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 8 |
| NM_001351102.2 | NP_001338031.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 9 |
| NM_001351103.2 | NP_001338032.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 10 |
| NM_001351104.2 | NP_001338033.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 11 |
| NM_001351105.2 | NP_001338034.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 12 |
| NM_001351106.2 | NP_001338035.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 13 |
| NM_001351107.2 | NP_001338036.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 14 |
| NM_001351108.2 | NP_001338037.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 15 |
| NM_001389594.1 | NP_001376523.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 16 |
| NM_001389595.1 | NP_001376524.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 17 |
| NM_001389596.1 | NP_001376525.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 18 |
| NM_001389597.1 | NP_001376526.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 19 |
| NM_001389598.1 | NP_001376527.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 20 |
| NM_001389599.1 | NP_001376528.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 21 |
| NM_001389600.1 | NP_001376529.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 22 |
| NM_001389601.1 | NP_001376530.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 23 |
| NM_001389602.1 | NP_001376531.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 24 |
| NM_001389603.1 | NP_001376532.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 25 |
| NM_001389604.1 | NP_001376533.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 26 |
| NM_001389605.1 | NP_001376534.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 27 |
| NM_001389606.1 | NP_001376535.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 28 |
| NM_001389607.1 | NP_001376536.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 29 |
| NM_001389608.1 | NP_001376537.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 30 |
| NM_001400288.1 | NP_001387217.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 16 |
| NM_001400290.1 | NP_001387219.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 36 |
| NM_001400292.1 | NP_001387221.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 2 |
| NM_001400293.1 | NP_001387222.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 20 |
| NM_001400294.1 | NP_001387223.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 31 |
| NM_001400295.1 | NP_001387224.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 32 |
| NM_001400296.1 | NP_001387225.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 33 |
| NM_001400297.1 | NP_001387226.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 14 |
| NM_001400298.1 | NP_001387227.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 34 |
| NM_001400299.1 | NP_001387228.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 35 |
| NM_006677.3 | NP_006668.1 | ubiquitin carboxyl-terminal hydrolase 19 isoform 4 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables Hsp90 protein binding |
IDA
IDA: Inferred from direct assay
|
24356957 | GOA |
| enables cysteine-type deubiquitinase activity |
IDA
IDA: Inferred from direct assay
|
19465887 | GOA |
| enables cysteine-type deubiquitinase activity |
IMP
IMP: Inferred from mutant phenotype
|
24356957 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19465887 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in ERAD pathway |
IDA
IDA: Inferred from direct assay
|
19465887 | GOA |
| involved in protein deubiquitination |
IMP
IMP: Inferred from mutant phenotype
|
24356957 | GOA |
| involved in protein stabilization |
IMP
IMP: Inferred from mutant phenotype
|
25088257 | GOA |
| involved in regulation of ERAD pathway |
IMP
IMP: Inferred from mutant phenotype
|
25088257 | GOA |
| involved in regulation of cellular response to hypoxia |
IMP
IMP: Inferred from mutant phenotype
|
22128162 | GOA |
| involved in response to endoplasmic reticulum stress |
IEP
IEP: Inferred from expression pattern
|
19465887 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
24356957 | GOA |
| located in endoplasmic reticulum membrane |
IDA
IDA: Inferred from direct assay
|
19465887 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
USP19 Protein Structure
CS
CS: CS domain (119 - 191)
CS
CS: CS domain (287 - 374)
UCH
UCH: Ubiquitin carboxyl-terminal hydrolase (497 - 1211)
zf-MYND
zf-MYND: MYND finger (791 - 833)
- 0
- 300
- 600
- 900
- 1200
- 1318 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ubiquitin carboxyl-terminal hydrolase 19 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pitt-Hopkins-Like Syndrome 2 |
|
|
| Autosomal Dominant Cerebellar Ataxia |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS15529 | USP19 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS18413 | Usp19 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS24894 | Usp19 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | USP19 | MGD | MGI:1918722 |
| Felis catus | USP19 | VGNC | VGNC:66871 |
| Canis familiaris | USP19 | VGNC | VGNC:48181 |
| Bos taurus | USP19 | VGNC | VGNC:36714 |
| Macaca mulatta | USP19 | VGNC | VGNC:78739 |
| Rattus norvegicus | USP19 | RGD | RGD:1303276 |
| Others | USP19 | NCBI |
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