LGALS3BP - galectin 3 binding protein Gene

Homo sapiens

Also known as 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B

Gene ID: 3959 | Gene type: protein coding

About LGALS3BP

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,971,255-78,979,923 (from NCBI)

This gene has 19 transcripts (splice variants), 254 orthologues and 15 paralogues. Ubiquitous expression in stomach (RPKM 179.8), colon (RPKM 156.8) and 25 other tissues.

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with Cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds Galectin 1. [provided by RefSeq, Jul 2008]

LGALS3BP Products(1)

mRNA	Protein	Name
NM_005567.4	NP_005558.1	galectin-3-binding protein precursor

LGALS3BP Protein Structure

SRCR

BACK

0
100
200
300
400
500
585 a.a.

Protein Preferred Names

Protein Names

galectin-3-binding protein

L3 antigen

Related Diseases

Diseases

Alias

Varicose Veins

Varices	Varix
Venous Ectasia	Venous Varices
Varicosity

Strongyloidiasis

Disseminated Strongyloidiasis	Anguilluliasis
Anguillulosis	Infection By Strongyloides
Threadworm Infection	Enterobiasis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Esophageal Varix

Esophageal Varices	Bleeding Esophageal Varices
Bleeding Oesophageal Varices	Esophageal Varices In Disease Classified Elsewhere, With Bleeding
Esophageal Varices With Bleeding	Esophageal Varices With Bleeding In Disease Ec
Esophageal Varices Without Bleeding	Esophageal Varices Without Mention Of Bleeding

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07605	LGALS3BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LGALS3BP	MGD	MGI:99554
Rattus norvegicus	LGALS3BP	RGD	RGD:620837
Bos taurus	LGALS3BP	VGNC	VGNC:30853
Macaca mulatta	LGALS3BP	VGNC	VGNC:74256

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