LGALS3BP - galectin 3 binding protein Gene

Also Known as 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3959

About LGALS3BP

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,971,255-78,979,923 (from NCBI)

This gene has 19 transcripts (splice variants), 254 orthologues and 15 paralogues. Ubiquitous expression in stomach (RPKM 179.8), colon (RPKM 156.8) and 25 other tissues.

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with Cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds Galectin 1. [provided by RefSeq, Jul 2008]

LGALS3BP Products (1)

mRNA Protein Name
NM_005567.4 NP_005558.1 galectin-3-binding protein precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
26618866 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
25645918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS3BP Protein Structure

SRCR

SRCR: Scavenger receptor cysteine-rich domain (28 - 124)

BACK

BACK: BTB And C-terminal Kelch (261 - 358)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 585 a.a.
Protein Preferred Names Protein Names

galectin-3-binding protein

  • L3 antigen

LGALS3BP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
LGALS3BP Q08380 VAMP5 Homo sapiens O95183
Pull Down
30833792
Intra
LGALS3BP Q08380 SAMHD1 Homo sapiens Q9Y3Z3
Pull Down
30833792
Intra
LGALS3BP Q08380 BCL2L14 Homo sapiens Q9BZR8
Pull Down
30833792
Intra
LGALS3BP Q08380 CFTR Homo sapiens P13569
Anti Bait CoIP
26618866
Intra
LGALS3BP Q08380 FBXO6 Homo sapiens Q9NRD1
Pull Down
30833792
Intra
LGALS3BP Q08380 TNFRSF10A Homo sapiens O00220
Pull Down
30833792
Intra
LGALS3BP Q08380 MX1 Homo sapiens P20591
Pull Down
30833792
Cross: Cross-species interaction Intra: Intraspecies interaction

LGALS3BP Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83426 LGALS3BP Antibody (YA3171) WB, FC Human, Mouse, Rat
HY-P83426A LGALS3BP Antibody (YA3171)(PBS only) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Varicose Veins

  • Varices

  • Varix

  • Venous Ectasia

  • Venous Varices

  • Varicosity
Strongyloidiasis

  • Disseminated Strongyloidiasis

  • Anguilluliasis

  • Anguillulosis

  • Infection By Strongyloides

  • Threadworm Infection

  • Enterobiasis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Esophageal Varix

  • Esophageal Varices

  • Bleeding Esophageal Varices

  • Bleeding Oesophageal Varices

  • Esophageal Varices In Disease Classified Elsewhere, With Bleeding

  • Esophageal Varices With Bleeding

  • Esophageal Varices With Bleeding In Disease Ec

  • Esophageal Varices Without Bleeding

  • Esophageal Varices Without Mention Of Bleeding
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07605 LGALS3BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19847 Lgals3bp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26345 Lgals3bp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P992257 Anti-LGALS3BP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LGALS3BP MGD MGI:99554
Rattus norvegicus LGALS3BP RGD RGD:620837
Bos taurus LGALS3BP VGNC VGNC:30853
Macaca mulatta LGALS3BP VGNC VGNC:74256
Others LGALS3BP NCBI