1. Apoptosis
    Epigenetics
    Cell Cycle/DNA Damage
  2. Apoptosis
    Caspase
    PARP
  3. 5,​7,​4'-​Trimethoxyflavone

5,​7,​4'-​Trimethoxyflavone 

Cat. No.: HY-N6818 Purity: 99.78%
Handling Instructions

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner.

For research use only. We do not sell to patients.

5,​7,​4'-​Trimethoxyflavone Chemical Structure

5,​7,​4'-​Trimethoxyflavone Chemical Structure

CAS No. : 5631-70-9

Size Price Stock Quantity
5 mg USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 202 In-stock
Estimated Time of Arrival: December 31
20 mg USD 343 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1].

IC50 & Target

Caspase-3

 

PARP

 

Molecular Weight

312.32

Formula

C₁₈H₁₆O₅

CAS No.

5631-70-9

SMILES

COC1=C(C(C=C(C2=CC=C(OC)C=C2)O3)=O)C3=CC(OC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (320.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2018 mL 16.0092 mL 32.0184 mL
5 mM 0.6404 mL 3.2018 mL 6.4037 mL
10 mM 0.3202 mL 1.6009 mL 3.2018 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.78%

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Keywords:

5,​7,​4'-​TrimethoxyflavoneApoptosisCaspasePARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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Product Name:
5,​7,​4'-​Trimethoxyflavone
Cat. No.:
HY-N6818
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