1. Saccharides and Glycosides
    Flavonoids
  2. Neohesperidin

Neohesperidin (Synonyms: Hesperetin 7-O-neohesperidoside)

Cat. No.: HY-N0101 Purity: 96.74%
Handling Instructions

Neohesperidin is a flavonoid compound found in high amounts in Poncirus trifoliata with anti-oxidant and anti-inflammatory effects.

For research use only. We do not sell to patients.

Neohesperidin Chemical Structure

Neohesperidin Chemical Structure

CAS No. : 13241-33-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 70 In-stock
Estimated Time of Arrival: December 31
500 mg USD 220 In-stock
Estimated Time of Arrival: December 31
1 g USD 390 In-stock
Estimated Time of Arrival: December 31
5 g USD 790 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Neohesperidin is a flavonoid compound found in high amounts in Poncirus trifoliata with anti-oxidant and anti-inflammatory effects.

In Vitro

Neohesperidin induces cell apoptosis in human breast adenocarcinoma MDA-MB-231 cells. The IC50 values of neohesperidin at 24 and 48 h are 47.4±2.6 μM and 32.5±1.8 μM, respectively. The expressions of P53 and Bax in the neohesperidin-treated cells are significantly up-regulated, while that of Bcl-2 is down-regulated[1]. Neohesperidin exhibits antioxidant activity (IC50=22.31 μg/mL) in the DPPH radical-scavenging assay[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Neohesperidin (50 mg/kg) significantly inhibits 55.0% of HCl/ethanol-induced gastric lesions. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreases the volume of gastric secretion and gastric acid output, and increases the pH[1]. Treatment of neohesperidin significantly decreases fasting glucose, serum glucose, and glycosylated serum protein (GSP) in mice. It significantly elevates oral glucose tolerance and insulin sensitivity and decreases insulin resistance in the diabetic mice. Neohesperidin significantly decreases serum triglycerides, total cholesterol, leptin level, and liver index in the mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

610.56

Formula

C₂₈H₃₄O₁₅

CAS No.

13241-33-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (163.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6378 mL 8.1892 mL 16.3784 mL
5 mM 0.3276 mL 1.6378 mL 3.2757 mL
10 mM 0.1638 mL 0.8189 mL 1.6378 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[3]

Mice: All the mice are fasted 6 h before the test and then fed with water or neohesperidin by gavage. The mice are intraperitoneally injected with either 2 g/kg BW glucose or 1 IU/kg BW insulin for OGTT and ITT, respectively. Blood samples are collected from the tail vein for the measurement of basal blood glucose levels (0 min) before the injection of glucose or insulin. Additional blood glucose levels are measured at 30, 60, 90 and 120 min[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

NeohesperidinHesperetin 7-O-neohesperidosideOthersInhibitorinhibitorinhibit

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Product Name:
Neohesperidin
Cat. No.:
HY-N0101
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