1. Autophagy
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Autophagy
    Reactive Oxygen Species
  3. Hesperidin

Hesperidin (Synonyms: Hesperetin 7-rutinoside)

Cat. No.: HY-15337 Purity: 97.00%
Handling Instructions

Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange.

For research use only. We do not sell to patients.

Hesperidin Chemical Structure

Hesperidin Chemical Structure

CAS No. : 520-26-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 108 In-stock
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100 mg USD 144 In-stock
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200 mg USD 192 In-stock
Estimated Time of Arrival: December 31
500 mg USD 228 In-stock
Estimated Time of Arrival: December 31
1 g USD 348 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Hesperidin purchased from MCE. Usage Cited in: Cell Rep. 2017 Nov 21;21(8):2147-2159.

    U2OS cells expressing Myc-tagged PLK1 WT, K492R, or SUMO-1-K492R are treated with Taxol for 16 hr. Half of the cells are then released in the presence of Hesperidin for 45 min to enrich cells at the later stage of M phase. Cell lysates are subject to IP, followed by western blot.
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    Description

    Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1] IC50: hesperidin (IC50=116.68μmo/L))[4] in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2] in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]

    Clinical Trial
    Molecular Weight

    610.56

    Formula

    C₂₈H₃₄O₁₅

    CAS No.

    520-26-3

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 33 mg/mL (54.05 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6378 mL 8.1892 mL 16.3784 mL
    5 mM 0.3276 mL 1.6378 mL 3.2757 mL
    10 mM 0.1638 mL 0.8189 mL 1.6378 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    HesperidinHesperetin 7-rutinosideAutophagyReactive Oxygen SpeciesInhibitorinhibitorinhibit

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    Product name:
    Hesperidin
    Cat. No.:
    HY-15337
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