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Hesperidin (Synonyms: Hesperetin 7-rutinoside)

Cat. No.: HY-15337 Purity: 97.47%
Data Sheet SDS Handling Instructions

Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange.

For research use only. We do not sell to patients.
Hesperidin Chemical Structure

Hesperidin Chemical Structure

CAS No. : 520-26-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $90 In-stock
100 mg $120 In-stock
200 mg $160 In-stock
500 mg $190 In-stock
1 g $290 In-stock
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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1] IC50: hesperidin (IC50=116.68μmo/L))[4] in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2] in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01881204 Purdue University|Nestec Ltd. Osteoporosis, Postmenopausal April 2011
NCT00914251 University of Rome Tor Vergata Endothelial Dysfunction|Metabolic Syndrome November 2008 Phase 2
NCT01773486 University of Maryland Obesity|Insulin Resistance June 2015 Phase 2
NCT00545116 Nestlé|National University of Malaysia Osteopenia|Osteoporosis October 2007 Phase 2
NCT02610491 Maastricht University Medical Center Metabolic Syndrome|Obesity February 2015 Phase 2
NCT02927483 SunWave Pharma|Opera Contract Research Organization SRL Chronic Venous Insufficiency November 2016 Phase 3
NCT00330096 Nestlé|Institut National de la Recherche Agronomique|Centre de Recherche en Nutrition Humaine. Clermont-Ferrand, France Osteoporosis, Osteopenia March 2006 Phase 3
NCT01477281 Laboratório Teuto Brasileiro S/A Chronic Venous Insufficiency|Disease February 2012 Phase 3
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Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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