1. Apoptosis
    Autophagy
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Apoptosis
    Autophagy
    Reactive Oxygen Species
    Endogenous Metabolite
  3. Hesperidin

Hesperidin (Synonyms: Hesperetin 7-rutinoside)

Cat. No.: HY-15337 Purity: 97.00%
Handling Instructions

Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreases inflammatory mediators and exerts significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities.

For research use only. We do not sell to patients.

Hesperidin Chemical Structure

Hesperidin Chemical Structure

CAS No. : 520-26-3

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10 mM * 1 mL in DMSO USD 66 In-stock
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100 mg USD 144 In-stock
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200 mg USD 192 In-stock
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500 mg USD 228 In-stock
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1 g USD 348 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Hesperidin purchased from MCE. Usage Cited in: Cell Rep. 2017 Nov 21;21(8):2147-2159.

    U2OS cells expressing Myc-tagged PLK1 WT, K492R, or SUMO-1-K492R are treated with NSC 125973 for 16 hr. Half of the cells are then released in the presence of Hesperidin for 45 min to enrich cells at the later stage of M phase. Cell lysates are subject to IP, followed by western blot.
    • Biological Activity

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    • Customer Review

    Description

    Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreases inflammatory mediators and exerts significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Hesperidin (5-200 µM; 24-72 h) induces potent cytotoxic effects in human osteosarcoma MG-63 cells[1].
    Hesperidin (5-150 µM; 48 h) induces early and late apoptosis in MG-63 cells[1].
    Hesperidin (10-30 µM) inhibits the activity of COX-2 and iNOS in a dose dependent manner in RAW 264.7 cells activated with LPS[2].
    Hesperidin (0.1 μg/mL; 2 h) decreases the formation of MDA and intracellular ROS, including chondrocyte apoptosis[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: MG-63 cells
    Concentration: 0, 5, 25, 50, 100, 150, 200 µM
    Incubation Time: 24, 48, 72 hours
    Result: Led to time-dependent and concentration-dependent cytotoxic effects, with IC50s of 94.3, 78.6 and 63.3 µM at 24, 48 and 72 h, respectively.

    Apoptosis Analysis[1]

    Cell Line: MG-63 cells
    Concentration: 0, 5, 50, 150 µM
    Incubation Time: 48 hours
    Result: Increased the percentage of apoptotic cells from 4.7% to 17.9, 34.6 and 68.3% at the concentration of 0, 5, 50 and 150 µM, respectively.
    In Vivo

    Hesperidin (5-80 mg/kg; 2 weeks) significantly suppresses MG-63 tumor growth in mice[1].
    Hesperidin (200 mg/kg; once daily for 28 d) markedly attenuates cartilage destruction and reduces IL-1β and TNF-α levels in a surgically-induced osteoarthritis (OA) rats[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    610.56

    Formula

    C₂₈H₃₄O₁₅

    CAS No.

    520-26-3

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 33 mg/mL (54.05 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6378 mL 8.1892 mL 16.3784 mL
    5 mM 0.3276 mL 1.6378 mL 3.2757 mL
    10 mM 0.1638 mL 0.8189 mL 1.6378 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    HesperidinHesperetin 7-rutinosideApoptosisAutophagyReactive Oxygen SpeciesEndogenous MetaboliteflavanoneglycosidecitrusinflammatoryantioxidantantiallergicantitumorInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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