1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Liquiritin

Liquiritin 

Cat. No.: HY-N0376 Purity: 98.07%
Handling Instructions

Liquiritin, a flavonoid isolated from Glycyrrhiza, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity.

For research use only. We do not sell to patients.

Liquiritin Chemical Structure

Liquiritin Chemical Structure

CAS No. : 551-15-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Liquiritin, a flavonoid isolated from Glycyrrhiza, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity[2].

IC50 & Target

IC50: 0.62 μM (AKR1C1), 0.61 μM (AKR1C2) and 3.72μM (AKR1C3)[1]

In Vitro

Liquiritin can target the residues Ala-27, Val-29, Ala-25, and Asn-56 of AKR1C1[1].
Liquiritin (50 μM; 6 hours) results in 85.00% of reduction in progesterone metabolism, which is mediated by Aldo-keto reductase family 1 member C1 (AKR1C1) enzymatic activity in HEC-1-B cells[1].
Liquiritin (100 µM) increases glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells[2].

Molecular Weight

418.39

Formula

C₂₁H₂₂O₉

CAS No.

551-15-5

SMILES

O=C1C[[email protected]@H](C2=CC=C(O[[email protected]]3[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O3)O)O)O)C=C2)OC4=CC(O)=CC=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (358.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3901 mL 11.9506 mL 23.9011 mL
5 mM 0.4780 mL 2.3901 mL 4.7802 mL
10 mM 0.2390 mL 1.1951 mL 2.3901 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LiquiritinReactive Oxygen SpeciesGlycyrrhizaAKR1C1progesteronemetabolismantioxidantneuroprotectiveanti-canceranti-inflammatoryInhibitorinhibitorinhibit

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Liquiritin
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HY-N0376
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