Narirutin
Based on 5 publication(s) in Google Scholar
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 14259-46-2
- Formula: C27H32O14
- Molecular Weight:580.53
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Narirutin
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Customer Validation & Images
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Bio/Physico-chemical Assay
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RT-PCR
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Histological Imaging/Staining
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WB
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Monocyte | IC50 |
>200 μM
Compound: Narirutin
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Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
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[PMID: 10096854] |
Narirutin (200 μM, 20 h) has no effect on the vitality of RBL-2H3 cells[3].
Narirutin (25 μM, 2.5 h) inhibits β-hex, histamine, IL-4 and TNF-a release were lower than 40% in RBL-2H3 cells. [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Narirutin (10 mg/kg, p.o ) block the OVA-induced increase in IL-4 but has no effect on the increase in IL-5 [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Allergic asthma female NC/Nga mice model[2]
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Dosage:0.1, 1 or 10 mg/kg
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Administration:Orally, 7d
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Result:Reduced eosinophil counts in peripheral blood.
Blocked the OVA-induced increase in IL-4.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 14259-46-2
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Appearance Solid
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Molecular Weight 580.53
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Formula C27H32O14
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Color White to light yellow
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SMILES
O=C(C[C@@H](C1=CC=C(O)C=C1)OC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO[C@H](O[C@@H](C)[C@H](O)[C@H]4O)[C@@H]4O)=C5)C2=C5O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 May 31:489:144992. PMID: 40466530 -
Biomed Pharmacother
Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. [Abstract]2023 Oct:166:115350. PMID: 37633055
Narirutin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Oct:166:115350. [Abstract]
Alanine transaminase (ALT) and aspartate transaminase (AST) activity in zebrafish larvae after alcoholic injury with or without Narirutin (NRT) (10, 40 μM) treatment.
Narirutin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Oct:166:115350. [Abstract]
Real-time PCR analysis of the mRNA levels of inflammatory response genes treated with Narirutin (NRT) (40 μM).
Narirutin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Oct:166:115350. [Abstract]
Oil-Red O staining was used to detect hepatic lipid accumulation in response to Narirutin (NRT) (10, 40 μM) treatment in zebrafish larvae.
Narirutin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Oct:166:115350. [Abstract]
Protein expression levels of Ddit3, Bip and Gapdh. Quantification of band intensity of Ddit3 and Bip was calculated by Gadph as a housekeeping protein treated with Narirutin (NRT) (40 μM).
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Solvent & Solubility
H2O : ≥ 100 mg/mL (172.26 mM)
DMSO : 100 mg/mL (172.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.08 mg/mL (3.58 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.08 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.58 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (17.23 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Sahu PK, et al. Structure-based Discovery of Narirutin as a Shikimate Kinase Inhibitor with Anti-tubercular Potency.Curr Comput Aided Drug Des. 2019 Oct 25. [Content Brief]
[2]. Funaguchi N, et al. Narirutin inhibits airway inflammation in an allergic mouse model.Clin Exp Pharmacol Physiol. 2007 Aug;34(8):766-70. [Content Brief]
[3]. Liyan Niu, et al. Inhibitory activity of narirutin on RBL-2H3 cells degranulation. Immunopharmacol Immunotoxicol. 2021, 43, 1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.7226 mL | 8.6128 mL | 17.2256 mL | 43.0641 mL |
| 5 mM | 0.3445 mL | 1.7226 mL | 3.4451 mL | 8.6128 mL | |
| 10 mM | 0.1723 mL | 0.8613 mL | 1.7226 mL | 4.3064 mL | |
| 15 mM | 0.1148 mL | 0.5742 mL | 1.1484 mL | 2.8709 mL | |
| 20 mM | 0.0861 mL | 0.4306 mL | 0.8613 mL | 2.1532 mL | |
| 25 mM | 0.0689 mL | 0.3445 mL | 0.6890 mL | 1.7226 mL | |
| 30 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4355 mL | |
| 40 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0766 mL | |
| 50 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.8613 mL | |
| 60 mM | 0.0287 mL | 0.1435 mL | 0.2871 mL | 0.7177 mL | |
| 80 mM | 0.0215 mL | 0.1077 mL | 0.2153 mL | 0.5383 mL | |
| 100 mM | 0.0172 mL | 0.0861 mL | 0.1723 mL | 0.4306 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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