Art. -Nr.: HY-W013372

7,8-Dihydroxyflavone

Name: 7,8-Dihydroxyflavone
Brand: MedChemExpress
SKU: HY-W013372
Price: 60.00 USD
Availability: InStock
Rating: 5 (24 reviews)

24 Cited Publications

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Based on 24 publication(s) in Google Scholar

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases.

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Reinheit : 99.58%
CAS. Nr.: 38183-03-8
Formel: C₁₅H₁₀O₄
Molecular Weight:254.24

Speicherung:

4°C, stored under nitrogen

* In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)

7,8-Dihydroxyflavone Chemical Structure

CAS. Nr.: 38183-03-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (24)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

TrkB

Alle Trk Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	37.25 μM Compound: 11a	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 22472167]
H9	EC₅₀	10 μM Compound: 10	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
H9	IC₅₀	14 μM Compound: 10	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
HEK293	IC₅₀	36 μM Compound: 1b	Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay	[PMID: 15588081]
HEK293	IC₅₀	36 μM Compound: Fig 20, R1C3	Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay	10.1039/C0MD00241K
MCF7	IC₅₀	27.5 μM Compound: 3c	The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells	[PMID: 11720850]
U-251	IC₅₀	50.11 μM Compound: 11a	Antiproliferative activity against human U251 cells after 24 hrs by MTT assay Antiproliferative activity against human U251 cells after 24 hrs by MTT assay	[PMID: 22472167]

In Vitro

7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease^[1].

Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 38183-03-8
Appearance Solid
Molecular Weight 254.24
Formel C₁₅H₁₀O₄
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, stored under nitrogen

* In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)

Publications (24)

All Cell Imaging/StainingWB

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Journal Impact Factor

Phytomedicine

Ligustilide covalently binds to Cys254 of the creatine kinase, M-type protein, ameliorating acute myocardial ischemia by enhancing the creatine phosphate level. [Abstract]

2025 Apr:139:156532. PMID: 40007343
Phytomedicine

Astragaloside IV mediates radiation-induced neuronal damage through activation of BDNF-TrkB signaling. [Abstract]

2024 Sep:132:155803. PMID: 38876008

7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Sep:132:155803. [Abstract]

7,8-Dihydroxyflavone (7,8-DHF; 500 nM; 24 h) showed protective effect in PC12 cells. Immunofluorescence staining of MAP-2 expression in PC12 cells.

7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Sep:132:155803. [Abstract]

7,8-Dihydroxyflavone (7,8-DHF; 500 nM; 24 h) decreased the expression of PSD-95 and F-actin in PC12 cells.

7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Sep:132:155803. [Abstract]

The expression levels of related proteins of BDNF-TrkB signaling pathway by western blot 7,8-Dihydroxyflavone (7,8-DHF; 500 nM).

7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Sep:132:155803. [Abstract]

The expression levels of related proteins of BDNF-TrkB signaling pathway by western blot 7,8-Dihydroxyflavone (7,8-DHF; 500 nM).

7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Sep:132:155803. [Abstract]

Immunofluorescence staining of MAP-2 expression primary cortical neurons treated with 7,8-Dihydroxyflavone (7,8-DHF; 500 nM; 24 h).
J Hazard Mater

Mechanistic exploration on neurodevelopmental toxicity induced by upregulation of alkbh5 targeted by triclosan exposure to larval zebrafish. [Abstract]

2023 Sep 5:457:131831. PMID: 37320907
Mol Psychiatry

Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes. [Abstract]

2022 Feb;27(2):1047-1058. PMID: 34642455
Free Radic Biol Med

7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression. [Abstract]

2025 Oct 30:242:275-287. PMID: 41173313
Aging Cell

Inhibition of Abnormal Elevated α-Synuclein Ameliorates Dopaminergic Neuron Degeneration in Parkinson's Disease Mouse Model. [Abstract]

2026 Oct;25(10):e70717. PMID: 42775696
J Agric Food Chem

Fluoride Stimulates Anxiety- and Depression-like Behaviors Associated with SIK2-CRTC1 Signaling Dysfunction. [Abstract]

2021 Nov 17;69(45):13618-13627. PMID: 34735150
Ecotoxicol Environ Saf

Amelioration of cholesterol sulfate for lead-induced CTX cell apoptosis based on BDNF signaling pathway mediated cholesterol metabolism. [Abstract]

2022 Dec 15:248:114307. PMID: 36423370
Drug Des Devel Ther

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway. [Abstract]

2021 Mar 30:15:1409-1422. PMID: 33833500
Colloids Surf B Biointerfaces

Drug-reinforced metal-organic framework nanozyme for combined treatment of ischemia/reperfusion acute kidney injury. [Abstract]

2026 Jun:262:115514. PMID: 41671821
Colloids Surf B Biointerfaces

pH-Responsive 7,8-DHF/HZIF-8@PLGA microspheres for modulating the osteoporotic microenvironment: Osteogenesis, immunomodulation, and ROS scavenging. [Abstract]

2026 May 22:266:115841. PMID: 42208272
Eur J Pharmacol

7,8-Dihydroxyflavone alleviates cardiac fibrosis by restoring circadian signals via downregulating Bmal1/Akt pathway. [Abstract]

2023 Jan 5:938:175420. PMID: 36427535
Sci Rep

Bupivacaine reduces GlyT1 expression by potentiating the p-AMPKα/BDNF signalling pathway in spinal astrocytes of rats. [Abstract]

2022 Jan 26;12(1):1378. PMID: 35082359
Exp Neurol

2026 Aug 17:407:115978. PMID: 42607921
Neuropharmacology

Excessive calpain impairs offspring cognition via BDNF/TrkB dysregulation after maternal non-obstetric surgery during pregnancy. [Abstract]

2025 Dec 15:281:110701. PMID: 41043554
Int J Med Sci

7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway. [Abstract]

2022 Jan 1;19(1):13-24. PMID: 34975295
Basic Clin Pharmacol Toxicol

7,8-Dihydroxyflavone Suppresses Experimental Pulmonary Fibrosis by Inhibiting Fibroblast-to-Myofibroblast Transformation and Epithelial-Mesenchymal Transition. [Abstract]

2026 Jan;138(1):e70158. PMID: 41347324
Toxicol Appl Pharmacol

7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway. [Abstract]

2025 Dec:505:117578. PMID: 40992637
Toxicol Appl Pharmacol

BDNF mimetics recover palmitic acid-induced injury in cardiomyocytes by ameliorating Akt-dependent mitochondrial impairments. [Abstract]

2024 May:486:116951. PMID: 38705401
PeerJ

7,8-Dihydroxyflavone protects neurons against oxygen-glucose deprivation induced apoptosis and activates the TrkB/Akt pathway. [Abstract]

2022 Feb 15:10:e12886. PMID: 35186478
Toxicol In Vitro

2026 Dec:117:106291. PMID: 42551611
Sleep Breath

7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF/TrkB signaling pathway. [Abstract]

2022 Mar;26(1):287-295. PMID: 33993395
Pharmacological Research Modern Chinese Medicine

2025 Sep 20;17:100693.
Evid Based Complement Alternat Med

Electroacupuncture Alleviates Visceral Hypersensitivity in IBS-D Rats by Inhibiting EGCs Activity through Regulating BDNF/TrkB Signaling Pathway. [Abstract]

2022 Feb 14;2022:2497430. PMID: 35198032

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (393.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9333 mL

19.6665 mL

39.3329 mL

5 mM

0.7867 mL

3.9333 mL

7.8666 mL

10 mM

0.3933 mL

1.9666 mL

3.9333 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9333 mL	19.6665 mL	39.3329 mL	98.3323 mL
	5 mM	0.7867 mL	3.9333 mL	7.8666 mL	19.6665 mL
	10 mM	0.3933 mL	1.9666 mL	3.9333 mL	9.8332 mL
	15 mM	0.2622 mL	1.3111 mL	2.6222 mL	6.5555 mL
	20 mM	0.1967 mL	0.9833 mL	1.9666 mL	4.9166 mL
	25 mM	0.1573 mL	0.7867 mL	1.5733 mL	3.9333 mL
	30 mM	0.1311 mL	0.6555 mL	1.3111 mL	3.2777 mL
	40 mM	0.0983 mL	0.4917 mL	0.9833 mL	2.4583 mL
	50 mM	0.0787 mL	0.3933 mL	0.7867 mL	1.9666 mL
	60 mM	0.0656 mL	0.3278 mL	0.6555 mL	1.6389 mL
	80 mM	0.0492 mL	0.2458 mL	0.4917 mL	1.2292 mL
	100 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.9833 mL

Bioz

Keywords

7,8-Dihydroxyflavone

24 Cited Publications

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7,8-Dihydroxyflavone

Publications Citing Use of MedChemExpress (MCE) 7,8-Dihydroxyflavone

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