country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

PDIA3 - protein disulfide isomerase family A member 3 Gene

Also Known as P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2923

About PDIA3

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,746,438-43,773,278 (from NCBI)

This gene has 33 transcripts (splice variants), 222 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 333.0), prostate (RPKM 175.9) and 25 other tissues.

Summary

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

PDIA3 Products (2)

mRNA	Protein	Name
NM_005313.5	NP_005304.3	protein disulfide-isomerase A3 precursor
NM_005313.5	NP_005304.3	protein disulfide-isomerase A3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16905107	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15896298	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	16677074	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptide antigen assembly with MHC class I protein complex	IDA IDA: Inferred from direct assay	17603487	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MHC class I peptide loading complex	IDA IDA: Inferred from direct assay	17947644	GOA
part of Tapasin-ERp57 complex	IPI IPI: Inferred from physical interaction	19119025	GOA
located in cell surface	IDA IDA: Inferred from direct assay	19995400	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23826168	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19995400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA3 Protein Structure

Thioredoxin

Thioredoxin_6

Thioredoxin

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
protein disulfide-isomerase A3	58 kDa glucose-regulated protein 58 kDa microsomal protein ER protein 57 ER protein 60 disulfide isomerase ER-60 endoplasmic reticulum P58 endoplasmic reticulum resident protein 57 endoplasmic reticulum resident protein 60 epididymis secretory protein Li 269 epididymis secretory sperm binding protein Li 93n glucose regulated protein, 58kDa phospholipase C-alpha protein disulfide isomerase-associated 3

PDIA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDIA3	P30101	PRDX4	Homo sapiens	Q13162	Enzymatic Study	21057456
Intra	PDIA3	P30101	STIM1	Homo sapiens	Q13586	SPR	21941299
Intra	PDIA3	P30101	STIM1	Homo sapiens	Q13586	IF	21941299
Intra	PDIA3	P30101	APP	Homo sapiens	P05067	Pull Down	15896298
Cross	PDIA3	P30101	CANX	Canis familiaris	P24643	NMR	16905107
Cross	PDIA3	P30101	CANX	Canis familiaris	P24643	ITC	16905107
Cross	PDIA3	P30101	Calr	Rattus norvegicus	P18418	Pull Down	22665516

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDIA3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71148	PDIA3 Protein, Human (HEK293, His)	P30101 (S25-L505)	≥ 90%, as determined by reducing SDS-PAGE.

PDIA3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83555	ERp57 Antibody (YA3300)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Granulomatous Orchitis	Non-Specific Granulomatous Orchitis
Macular Degeneration, Age-Related, 15	Age Related Macular Degeneration 15 ARMD15 Macular Degeneration, Age-Related, 15, Susceptibility To Macular Degeneration, Age-Related, Type 15
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0177	Diosgenin	Inhibitor	99.92%	Unkown
HY-100432	LOC14		98.0%	Unkown
HY-122895	E64FC26		98.48%	Unkown
HY-122895A	(E/Z)-E64FC26		99.80%	Unkown
HY-RS10266	PDIA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10267	Pdia3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-151286	Antitumor agent-73	Inhibitor	/	Unkown
HY-170655	PDI-IN-4	Inhibitor	/	Unkown
HY-P11857	Alkyne-GRWHPM-CONH-NH-CMK	Inhibitor	/	Unkown
HY-RS10268	Pdia3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PDIA3	VGNC	VGNC:67483
Mus musculus	PDIA3	MGD	MGI:95834
Bos taurus	PDIA3	VGNC	VGNC:32697
Canis familiaris	PDIA3	VGNC	VGNC:103695
Rattus norvegicus	PDIA3	RGD	RGD:68430
Macaca mulatta	PDIA3	VGNC	VGNC:75905
Others	PDIA3	NCBI