Antitumor agent-73
Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin.
For research use only. We do not sell to patients.
- CAS No.: 2812356-72-0
- Formula: C50H82BrO4P
- Molecular Weight:858.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
STAT3 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| ASPC1 | IC50 |
0.1847 μM
Compound: 2.2f
|
Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
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[PMID: 35586422] |
| HCT-116 | IC50 |
4.001 μM
Compound: 2.2f
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
|
[PMID: 35586422] |
| NCI-H358 | IC50 |
4.038 μM
Compound: 2.2f
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Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
|
[PMID: 35586422] |
| SW-620 | IC50 |
0.4483 μM
Compound: 2.2f
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Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
|
[PMID: 35586422] |
Antitumor agent-73 (compound 2.2f) shows anti-proliferative activity against cancer cells with IC50s of 0.1847 μM (Aspc-1), 4.038 μM (H358), 4.001 μM (HCT116), 0.4483 μM (SW620), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2812356-72-0
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Molecular Weight 858.06
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Formula C50H82BrO4P
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SMILES
C[C@]1(CC2)C(C[C@H]2OC(CCCC[P+](C3CCCCC3)(C4CCCCC4)C5CCCCC5)=O)=CC[C@]6([H])[C@]1([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@@]9(CC[C@H](CO9)C)O8.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-73 Related Classifications
HY-151286 Related Classifications
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