2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. Antitumor agent-73

Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin.

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Antitumor agent-73

Antitumor agent-73 Chemical Structure

CAS No. : 2812356-72-0

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Antitumor agent-73 Related Antibodies

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Description

Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin[1].

IC50 & Target

STAT3

 

Cellular Effect
Cell Line Type Value Description References
ASPC1 IC50
0.1847 μM
Compound: 2.2f
Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 35586422]
HCT-116 IC50
4.001 μM
Compound: 2.2f
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 35586422]
NCI-H358 IC50
4.038 μM
Compound: 2.2f
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 35586422]
SW-620 IC50
0.4483 μM
Compound: 2.2f
Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 35586422]
In Vitro

Antitumor agent-73 (compound 2.2f) shows anti-proliferative activity against cancer cells with IC50s of 0.1847 μM (Aspc-1), 4.038 μM (H358), 4.001 μM (HCT116), 0.4483 μM (SW620), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-73 Related Antibodies
Molecular Weight

858.06

Formula

C50H82BrO4P
CAS No.
SMILES

C[C@]1(CC2)C(C[C@H]2OC(CCCC[P+](C3CCCCC3)(C4CCCCC4)C5CCCCC5)=O)=CC[C@]6([H])[C@]1([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@@]9(CC[C@H](CO9)C)O8.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-73 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-732812356-72-0Antitumor agent73Antitumor agent 73STATDiosgeninderivativeSTAT3Pdia3/ERp57antitumorAspc-1H358HCT116SW620Inhibitorinhibitorinhibit

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