1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. Diosgenin


Cat. No.: HY-N0177 Purity: >98.0%
Handling Instructions

Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway. Diosgenin is an exogenous activator of Pdia3/ERp57.

For research use only. We do not sell to patients.

Diosgenin Chemical Structure

Diosgenin Chemical Structure

CAS No. : 512-04-9

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Diosgenin:

Top Publications Citing Use of Products

Publications Citing Use of MCE Diosgenin

    Diosgenin purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2016;39(4):1626-37.

    Arithmetic means ± SEM (n = 10) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Diosgenin (5-15 µM).

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2].

    IC50 & Target[1]



    In Vitro

    In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[3]. Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibition occurring at around 100 μM[1].

    In Vivo

    Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice[4].

    Molecular Weight




    CAS No.



    [[email protected]@H]1(O)CC2[[email protected]](C)(CC1)[[email protected]]1([H])[[email protected]]([H])([[email protected]@]3([H])[[email protected]@](CC1)(C)[[email protected]@]1([H])[[email protected]](C)[[email protected]]4(OC[[email protected]](C)CC4)O[[email protected]@]1([H])C3)CC=2 |&1:0,4,8,10,12,14,18,20,22,25,30,r|


    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    Ethanol : 6.67 mg/mL (16.09 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4118 mL 12.0592 mL 24.1185 mL
    5 mM 0.4824 mL 2.4118 mL 4.8237 mL
    10 mM 0.2412 mL 1.2059 mL 2.4118 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.67 mg/mL (1.62 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.67 mg/mL (1.62 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% EtOH    90% corn oil

      Solubility: ≥ 0.67 mg/mL (1.62 mM); Clear solution

    *All of the co-solvents are provided by MCE.
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