HMMR - hyaluronan mediated motility receptor Gene

Also Known as CD168; IHABP; RHAMM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3161

About HMMR

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:163,460,632-163,491,941 (from NCBI)

This gene has 8 transcripts (splice variants), 201 orthologues and is associated with 1 phenotype. Biased expression in testis (RPKM 12.7), lymph node (RPKM 9.0) and 11 other tissues.

Summary

The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with Other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast Cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

HMMR Products (4)

mRNA	Protein	Name
NM_001142556.2	NP_001136028.1	hyaluronan mediated motility receptor isoform a
NM_001142557.2	NP_001136029.1	hyaluronan mediated motility receptor isoform d
NM_012484.3	NP_036616.2	hyaluronan mediated motility receptor isoform b
NM_012485.3	NP_036617.2	hyaluronan mediated motility receptor isoform c

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22110403	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in spindle	IDA IDA: Inferred from direct assay	31338967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hyaluronan mediated motility receptor	intracellular hyaluronic acid-binding protein

HMMR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HMMR	O75330	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	25416956
Intra	HMMR	O75330	MORN4	Homo sapiens	Q8NDC4	Y2H Prey Pooling	25416956
Intra	HMMR	O75330	MORN4	Homo sapiens	Q8NDC4	Y2H Array	25416956
Intra	HMMR	O75330	TPX2	Homo sapiens	Q9ULW0	Anti Bait CoIP	22110403
Intra	HMMR	O75330	FAM83D	Homo sapiens	Q9H4H8	Anti Tag CoIP	33961781
Intra	HMMR	O75330	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	22110403

Cross: Cross-species interaction Intra: Intraspecies interaction

HMMR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81577	CD168 Antibody (YA1322)	WB, IHC-P, ICC/IF, FC	Human
HY-P83858	CD168 Antibody (YA3555)	FC, ELISA	Human
HY-P83858A	CD168 Antibody (YA3555)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06248	HMMR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HMMR	VGNC	VGNC:41718
Macaca mulatta	HMMR	VGNC	VGNC:73487
Rattus norvegicus	HMMR	RGD	RGD:2805
Bos taurus	HMMR	VGNC	VGNC:29884
Felis catus	HMMR	VGNC	VGNC:82481
Mus musculus	HMMR	MGD	MGI:104667
Others	HMMR	NCBI