TPX2 - TPX2 microtubule nucleation factor Gene

Also Known as DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22974

About TPX2

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,739,290-31,801,800 (from NCBI)

This gene has 2 transcripts (splice variants) and 209 orthologues. Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues.

Summary

Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule Cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

TPX2 Products (1)

mRNA	Protein	Name
NM_012112.5	NP_036244.2	targeting protein for Xklp2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables importin-alpha family protein binding	IDA IDA: Inferred from direct assay	26165940	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	37728657	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14580337	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	14580337	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	14580337	GOA
involved in microtubule nucleation	IDA IDA: Inferred from direct assay	26414402	GOA
involved in mitotic spindle assembly	IDA IDA: Inferred from direct assay	26165940	GOA
involved in negative regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	26414402	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in spindle	IDA IDA: Inferred from direct assay	37728657	GOA
colocalizes with spindle pole	IDA IDA: Inferred from direct assay	14718566	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPX2 Protein Structure

Aurora-A_bind

TPX2_importin

TPX2

0
200
400
600
747 a.a.

Protein Preferred Names	Protein Names
targeting protein for Xklp2	TPX2, microtubule-associated protein homolog

TPX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TPX2	Q9ULW0	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	TPX2	Q9ULW0	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	TPX2	Q9ULW0	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	TPX2	Q9ULW0	HMMR	Homo sapiens	O75330	Anti Bait CoIP	22110403
Intra	TPX2	Q9ULW0	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Intra	TPX2	Q9ULW0	AURKA	Homo sapiens	O14965	X-Ray Diffraction	14580337
Intra	TPX2	Q9ULW0	AURKA	Homo sapiens	O14965	Anti Bait CoIP	22110403
Intra	TPX2	Q9ULW0	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TPX2	Q9ULW0	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TPX2	Q9ULW0	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	TPX2	Q9ULW0	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	TPX2	Q9ULW0	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	TPX2	Q9ULW0	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

TPX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83540	TPX2 Antibody (YA3285)	WB, ICC/IF	Human
HY-P83540A	TPX2 Antibody (YA3285)(PBS only)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Capillary Leak Syndrome	Systemic Capillary Leak Syndrome Clarkson Disease Capillary Leak Syndrome With Monoclonal Gammopathy Scls Periodic Systemic Capillary Leak Syndrome Capillary Hyperpermeability Syndrome Idiopathic Capillary Leak Syndrome
Capillary Disease	Disease Of Capillaries
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122236	UMK57		99.51%	Unkown
HY-168022	CAM2602	Inhibitor	99.85%	Unkown
HY-125956	Aurkin A		98.0%	Unkown
HY-RS14959	TPX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-158038	AurkA allosteric-IN-1		/	Unkown
HY-183102	ATC12		/	Unkown
HY-RS19965	Tpx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26468	Tpx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TPX2	MGD	MGI:1919369
Rattus norvegicus	TPX2	RGD	RGD:1311894
Macaca mulatta	TPX2	VGNC	VGNC:78697
Canis familiaris	TPX2	VGNC	VGNC:47757
Bos taurus	TPX2	VGNC	VGNC:36266
Felis catus	TPX2	VGNC	VGNC:66489
Others	TPX2	NCBI