AURKA - aurora kinase A Gene

Also Known as AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; PPP1R47

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6790

About AURKA

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:56,369,390-56,392,215 (from NCBI)

This gene has 13 transcripts (splice variants), 232 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 12.9), lymph node (RPKM 6.9) and 16 other tissues.

Summary

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in Mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

AURKA Products (13)

mRNA	Protein	Name
NM_198437.3	NP_940839.1	aurora kinase A
NM_198436.3	NP_940838.1	aurora kinase A
XM_017028034.3	XP_016883523.1	aurora kinase A isoform X1
NM_198435.3	NP_940837.1	aurora kinase A
XM_047440427.1	XP_047296383.1	aurora kinase A isoform X1
NM_003600.4	NP_003591.2	aurora kinase A
XM_047440428.1	XP_047296384.1	aurora kinase A isoform X1
NM_001323304.2	NP_001310233.1	aurora kinase A
NM_198433.3	NP_940835.1	aurora kinase A
NM_001323303.2	NP_001310232.1	aurora kinase A
XM_017028035.2	XP_016883524.1	aurora kinase A isoform X2
NM_198434.3	NP_940836.1	aurora kinase A
NM_001323305.2	NP_001310234.1	aurora kinase A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular function activator activity	EXP EXP: Inferred from Experiment	12237287	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12244051	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	20460379	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	14580337	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18615013	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	13678582	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	28218735	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cilium disassembly	IMP IMP: Inferred from mutant phenotype	17604723	GOA
acts upstream of or within liver regeneration	IDA IDA: Inferred from direct assay	19435814	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28218735	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	21820309	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	28218735	GOA
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	21822277	GOA
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	21600873	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	21820309	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	15987997	GOA
acts upstream of or within response to wounding	IDA IDA: Inferred from direct assay	19435814	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	21820309	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	17726514	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	17604723	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	19801554	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	25657325	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20531406	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20531406	GOA
colocalizes with spindle microtubule	IDA IDA: Inferred from direct assay	19801554	GOA
located in spindle pole centrosome	IDA IDA: Inferred from direct assay	19801554	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AURKA Protein Structure

Pkinase

0
100
200
300
403 a.a.

Protein Preferred Names	Protein Names
aurora kinase A	aurora 2 aurora/IPL1-like kinase aurora/IPL1-related kinase 1 breast tumor-amplified kinase protein phosphatase 1, regulatory subunit 47 serine/threonine protein kinase 15 serine/threonine-protein kinase 6 serine/threonine-protein kinase aurora-A

AURKA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AURKA	O14965	TPX2	Homo sapiens	Q9ULW0	Anti Tag CoIP	19357306
Intra	AURKA	O14965	TPX2	Homo sapiens	Q9ULW0	Anti Bait CoIP	22110403
Intra	AURKA	O14965	TPX2	Homo sapiens	Q9ULW0	Anti Tag CoIP	33961781
Intra	AURKA	O14965	TPX2	Homo sapiens	Q9ULW0	TAP	20360068
Intra	AURKA	O14965	TPX2	Homo sapiens	Q9ULW0	Anti Tag CoIP	28514442
Intra	AURKA	O14965	INCENP	Homo sapiens	Q9NQS7-1	Protein Kinase Assay	19357306
Intra	AURKA	O14965	INCENP	Homo sapiens	Q9NQS7-1	Pull Down	19357306
Intra	AURKA	O14965	EGFR	Homo sapiens	P00533	Protein Array	23520446
Intra	AURKA	O14965	EGFR	Homo sapiens	P00533	PLA	23520446
Intra	AURKA	O14965	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	19357306
Intra	AURKA	O14965	TP73	Homo sapiens	O15350	Anti Bait CoIP	22340593
Intra	AURKA	O14965	SPAG5	Homo sapiens	Q96R06	Y2H	18361916
Intra	AURKA	O14965	SPAG5	Homo sapiens	Q96R06	Anti Bait CoIP	18361916
Intra	AURKA	O14965	PLK1	Homo sapiens	P53350	Anti Tag CoIP	18615013
Intra	AURKA	O14965	BIRC5	Homo sapiens	O15392	Protein Kinase Assay	19357306
Intra	AURKA	O14965	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	19357306
Intra	AURKA	O14965	IK	Homo sapiens	Q13123	Anti Tag CoIP	24996188
Intra	AURKA	O14965	IK	Homo sapiens	Q13123	Anti Bait CoIP	24996188
Intra	AURKA	O14965	BORA	Homo sapiens	Q6PGQ7	Pull Down	16890155
Intra	AURKA	O14965	BORA	Homo sapiens	Q6PGQ7	Anti Tag CoIP	18615013
Intra	AURKA	O14965	IKBKB	Homo sapiens	O14920	Protein Kinase Assay	17939994
Intra	AURKA	O14965	IKBKB	Homo sapiens	O14920	Anti Bait CoIP	17939994
Intra	AURKA	O14965	MYCN	Homo sapiens	P04198	Anti Bait CoIP	25175806
Intra	AURKA	O14965	MYCN	Homo sapiens	P04198	Anti Bait CoIP	23792191
Intra	AURKA	O14965	MYCN	Homo sapiens	P04198	Anti Bait CoIP	19111882
Cross	AURKA	O14965	Sirt2	Mus musculus	Q8VDQ8	Anti Tag CoIP	22014574
Cross	AURKA	O14965	Sirt2	Mus musculus	Q8VDQ8	IF	22014574
Cross	AURKA	O14965	Sirt2	Mus musculus	Q8VDQ8	Anti Bait CoIP	22014574

Cross: Cross-species interaction Intra: Intraspecies interaction

AURKA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80561	Aurora A Antibody (YA827)	WB, ICC/IF	Human, Monkey
HY-P80561A	Aurora A Antibody (YA827)(PBS only)	WB, ICC/IF	Human, Monkey
HY-P80971	Aurora A Antibody (YA859)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P83819	Aurora A Antibody (YA3516)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P83819A	Aurora A Antibody (YA3516)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P86641	Aurora A Antibody (YA6333)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Exudative Vitreoretinopathy 2, X-Linked	EVR2 Evrx Fevrx X-Linked Exudative Vitreoretinopathy 2 Exudative Vitreoretinopathy, Familial, 2 Fevr, X-Linked Vitreoretinopathy, Exudative 2 Exudative Vitreoretinopathy Familial 2 Fevr X-Linked X-Linked Familial Exudative Vitreoretinopathy Vitreoretinopathy, Exudative, X-Linked, Type 2 Exudative Vitreoretinopathy, Familial, X-Linked Recessive
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Spinal Ependymoma, Mycn
Tetraploidy	Tetraploidy Syndrome
Rhabdomyosarcoma
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Cycloplegia	Ciliary Muscle Paresis Cycloplegic Paralysis Of Accommodation Paresis Of Accommodation Visual Accommodation Paralysis Accommodation Paralysis Intrinsic Paralysis Of Eye Muscle Cycloplegic
Donohue Syndrome	Leprechaunism Leprechaunism Syndrome Donohue'S Syndrome LEPRCH
Joubert Syndrome 8	JBTS8 Joubert Syndrome, Type 8
Prostate Neuroendocrine Neoplasm	Neuroendocrine Tumor Of The Prostate
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11103	Sitaxsentan sodium		98.83%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157396	JAB-2485		99.87%	Phase 2
HY-172737	RP-1664	Inhibitor	98.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112273	CD532	Inhibitor	98.86%	Unkown
HY-103645	GW779439X		99.85%	Unkown
HY-125956	Aurkin A		98.0%	Unkown
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-171767	SK2188		99.87%	Unkown
HY-125911	Gossypin		98.29%	Unkown
HY-171768	SK2187	Degrader	95.81%	Unkown
HY-168543	PROTAC MPS1 degrader 2	Degrader	99.78%	Unkown
HY-112273A	CD532 hydrochloride	Inhibitor	99.62%	Unkown
HY-100865	BPR1K871	Inhibitor	99.12%	Unkown
HY-137344A	dAURK-4 hydrochloride	Inhibitor	98.14%	Unkown
HY-175525	MS44	Degrader	99.81%	Unkown
HY-181311	CCT400028		98.03%	Unkown
HY-168540	PROTAC MPS1 degrader 1	Degrader	99.90%	Unkown
HY-180132	PROTAC AURKA degrader 2	Degrader	98.36%	Unkown
HY-162469	6K465	Inhibitor	98.61%	Unkown
HY-114461B	(3S,17S)-FD-895		/	Unkown
HY-116190	CFI-401870	Inhibitor	/	Unkown
HY-125090	PHA-680626		/	Unkown
HY-137344	dAURK-4	Inhibitor	/	Unkown
HY-147703	Aurora kinase inhibitor-9	Inhibitor	/	Unkown
HY-155464	VEGFR-2/AURKA-IN-1	Chemical	/	Unkown
HY-158038	AurkA allosteric-IN-1		/	Unkown
HY-161407	AURKA-IN-1	Inhibitor	/	Unkown
HY-162837	AURKA against 1	Inhibitor	/	Unkown
HY-173499	HLDA-212		/	Unkown
HY-175827	MK-5108-NH-PEG2-alkyne	Inhibitor	/	Unkown
HY-175830	PROTAC AURKA degrader 1	Degrader	/	Unkown
HY-175982	AURKA-IN-3	Inhibitor	/	Unkown
HY-179375	LCI133	Inhibitor	/	Unkown
HY-179574	AURKA-IN-4	Inhibitor	99.88%	Unkown
HY-179640	SK4454	Degrader	/	Unkown
HY-179641	SK5527	Degrader	/	Unkown
HY-181231	PROTAC CDK9 degrader-12		/	Unkown
HY-181626	NN-01-195		/	Unkown
HY-183098	UNC8209		/	Unkown
HY-183100	UNC8461	Control	/	Unkown
HY-184329	PROTAC AURKB Degrader-1		/	Unkown
HY-RS01266	AURKA Human Pre-designed siRNA Set A		/	Unkown
HY-RS01267	Aurka Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01268	Aurka Rat Pre-designed siRNA Set A		/	Unkown
HY-181568	PROTAC Aurora A Degrader-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AURKA	VGNC	VGNC:70052
Bos taurus	AURKA	VGNC	VGNC:26349
Rattus norvegicus	AURKA	RGD	RGD:628895
Canis familiaris	AURKA	VGNC	VGNC:38311
Felis catus	AURKA	VGNC	VGNC:60042
Mus musculus	AURKA	MGD	MGI:894678
Others	AURKA	NCBI