PROTAC MPS1 degrader 1

Cat. No.: HY-168540 Purity: 99.90%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PROTAC MPS1 degrader 1 (Compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC₅₀s of 17.7, 108.7 and 570.3 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168542); Black: linker (HY-W141926); Blue: ligand for E3 ligase (HY-10984).

For research use only. We do not sell to patients.

PROTAC MPS1 degrader 1 Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PROTACs Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Aurora Kinase Isoform Specific Products:

View All Isoforms

Aurora Kinase Aurora A Aurora B Aurora C

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

TTK

17.7 nM (DC₅₀)

Aurora A

108.7 nM (DC₅₀)

Aurora B

570.3 nM (DC₅₀)

Molecular Weight

818.88

Formula

C₄₁H₄₆N₁₂O₇

Appearance

Solid

Color

Off-white to gray

SMILES

O=C(NCC(N1CCN(C2=CC=C(NC3=NC(NC4CCCCC4)=C5N=CNC5=N3)C=C2)CC1)=O)CCCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (122.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2212 mL	6.1059 mL	12.2118 mL
5 mM	0.2442 mL	1.2212 mL	2.4424 mL
10 mM	0.1221 mL	0.6106 mL	1.2212 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (105 KB) RP-HPLC (131 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Sflakidou E, et, al. Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases. ACS Pharmacol. Transl. Sci. 2024.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2212 mL	6.1059 mL	12.2118 mL	30.5295 mL
	5 mM	0.2442 mL	1.2212 mL	2.4424 mL	6.1059 mL
	10 mM	0.1221 mL	0.6106 mL	1.2212 mL	3.0530 mL
	15 mM	0.0814 mL	0.4071 mL	0.8141 mL	2.0353 mL
	20 mM	0.0611 mL	0.3053 mL	0.6106 mL	1.5265 mL
	25 mM	0.0488 mL	0.2442 mL	0.4885 mL	1.2212 mL
	30 mM	0.0407 mL	0.2035 mL	0.4071 mL	1.0177 mL
	40 mM	0.0305 mL	0.1526 mL	0.3053 mL	0.7632 mL
	50 mM	0.0244 mL	0.1221 mL	0.2442 mL	0.6106 mL
	60 mM	0.0204 mL	0.1018 mL	0.2035 mL	0.5088 mL
	80 mM	0.0153 mL	0.0763 mL	0.1526 mL	0.3816 mL
	100 mM	0.0122 mL	0.0611 mL	0.1221 mL	0.3053 mL