1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase
  3. dAURK-4 hydrochloride

dAURK-4 hydrochloride 

Cat. No.: HY-137344A
Handling Instructions

dAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects.

For research use only. We do not sell to patients.

dAURK-4 hydrochloride Chemical Structure

dAURK-4 hydrochloride Chemical Structure

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Other Forms of dAURK-4 hydrochloride:

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Description

dAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects[1].

IC50 & Target[1]

Aurora A

 

In Vitro

dAURK-4 (125-1000 nM; 4-24 hours) hydrochloride shows degradation of AURKA in a dose-depended manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM.1S cells
Concentration: 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 4 hours or 24 hours
Result: Inhibited the protein level of AURKA (Aurora A).
Molecular Weight

1071.93

Formula

C52H53Cl2FN8O12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (62.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9329 mL 4.6645 mL 9.3290 mL
5 mM 0.1866 mL 0.9329 mL 1.8658 mL
10 mM 0.0933 mL 0.4664 mL 0.9329 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (4.66 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References
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Product Name:
dAURK-4 hydrochloride
Cat. No.:
HY-137344A
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