1. Cell Cycle/DNA Damage
  2. Aurora Kinase
  3. dAURK-4 hydrochloride

dAURK-4 hydrochloride 

Cat. No.: HY-137344A
Handling Instructions

dAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects.

For research use only. We do not sell to patients.

dAURK-4 hydrochloride Chemical Structure

dAURK-4 hydrochloride Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of dAURK-4 hydrochloride:

Top Publications Citing Use of Products

View All Aurora Kinase Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


dAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects[1].

IC50 & Target[1]

Aurora A


In Vitro

dAURK-4 (125-1000 nM; 4-24 hours) hydrochloride shows degradation of AURKA in a dose-depended manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM.1S cells
Concentration: 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 4 hours or 24 hours
Result: Inhibited the protein level of AURKA (Aurora A).
Molecular Weight





Room temperature in continental US; may vary elsewhere.


-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (62.20 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9329 mL 4.6645 mL 9.3290 mL
5 mM 0.1866 mL 0.9329 mL 1.8658 mL
10 mM 0.0933 mL 0.4664 mL 0.9329 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (4.66 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name



Applicant Name *


Email address *

Phone number *


Organization name *

Department *


Requested quantity *

Country or Region *



Bulk Inquiry

Inquiry Information

Product Name:
dAURK-4 hydrochloride
Cat. No.:
MCE Japan Authorized Agent: