1. Cell Cycle/DNA Damage Epigenetics
  2. Aurora Kinase
  3. dAURK-4

dAURK-4, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (dAURK-4 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

dAURK-4 Chemical Structure

dAURK-4 Chemical Structure

CAS No. : 2705844-81-9

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Description

dAURK-4, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects[1].

IC50 & Target[1]

Aurora A

 

In Vitro

dAURK-4 (125-1000 nM; 4-24 hours) shows degradation of AURKA in a dose-depended manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM.1S cells
Concentration: 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 4 hours or 24 hours
Result: Inhibited the protein level of AURKA (Aurora A).
Molecular Weight

1035.47

Formula

C52H52ClFN8O12

CAS No.
SMILES

O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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dAURK-4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
dAURK-4
Cat. No.:
HY-137344
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