2. PROTAC Cell Cycle/DNA Damage Epigenetics
  3. PROTACs Aurora Kinase
  4. dAURK-4

dAURK-4, an Alisertib (HY-10971) derivative, is a potent and selective AURKA (Aurora A) degrader, with anticancer effects.
(Pink: Aurora A and Aurora B ligand (HY-10971); Blue: Cereblon ligand (HY-103597); Black: linker (HY-W004640)).

For research use only. We do not sell to patients.

dAURK-4

dAURK-4 Chemical Structure

CAS No. : 2705844-81-9

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Other Forms of dAURK-4:

dAURK-4 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Aurora Kinase Isoform Specific Products:

View All Isoforms
Aurora Kinase Aurora A Aurora B Aurora C

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

dAURK-4, an Alisertib (HY-10971) derivative, is a potent and selective AURKA (Aurora A) degrader, with anticancer effects[1]. (Pink: Aurora A and Aurora B ligand (HY-10971); Blue: Cereblon ligand (HY-103597); Black: linker (HY-W004640)).

IC50 & Target[1]

Aurora A

 

In Vitro

dAURK-4 (125-1000 nM; 4-24 hours) shows degradation of AURKA in a dose-depended manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

dAURK-4 Related Antibodies

Cell Viability Assay[1]

Cell Line: MM.1S cells
Concentration: 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 4 hours or 24 hours
Result: Inhibited the protein level of AURKA (Aurora A).
Molecular Weight

1035.47

Formula

C52H52ClFN8O12
CAS No.
SMILES

O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (96.57 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9657 mL 4.8287 mL 9.6574 mL
5 mM 0.1931 mL 0.9657 mL 1.9315 mL
View the Complete Stock Solution Preparation Table

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9657 mL 4.8287 mL 9.6575 mL 24.1436 mL
5 mM 0.1931 mL 0.9657 mL 1.9315 mL 4.8287 mL
10 mM 0.0966 mL 0.4829 mL 0.9657 mL 2.4144 mL
15 mM 0.0644 mL 0.3219 mL 0.6438 mL 1.6096 mL
20 mM 0.0483 mL 0.2414 mL 0.4829 mL 1.2072 mL
25 mM 0.0386 mL 0.1931 mL 0.3863 mL 0.9657 mL
30 mM 0.0322 mL 0.1610 mL 0.3219 mL 0.8048 mL
40 mM 0.0241 mL 0.1207 mL 0.2414 mL 0.6036 mL
50 mM 0.0193 mL 0.0966 mL 0.1931 mL 0.4829 mL
60 mM 0.0161 mL 0.0805 mL 0.1610 mL 0.4024 mL
80 mM 0.0121 mL 0.0604 mL 0.1207 mL 0.3018 mL
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dAURK-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dAURK-42705844-81-9dAURK4dAURK 4PROTACsAurora KinaseAURKA degraderanticancer effectInhibitorinhibitorinhibit

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