Sirt2 - sirtuin 2 Gene

Also Known as Sir2l; SIR2L2; 5730427M03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64383

About Sirt2

Chromosome 7: 28,466,160-28,488,086 forward strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 187 orthologues, 6 paralogues and is associated with 24 phenotypes. Ubiquitous expression in testis adult (RPKM 56.8), cerebellum adult (RPKM 53.7) and 28 other tissues.

Summary

Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (Sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sirt2 Products (3)

mRNA Protein Name
NM_022432.4 NP_071877.3 NAD-dependent protein deacetylase sirtuin-2 isoform 1
NM_001122765.1 NP_001116237.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2
NM_001122766.1 NP_001116238.1 NAD-dependent protein deacetylase sirtuin-2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
34059674 MGI
enables histone deacetylase activity IMP
IMP: Inferred from mutant phenotype
24334550 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17521387 MGI
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
17681146 MGI
enables protein lysine deacetylase activity IMP
IMP: Inferred from mutant phenotype
17521387 MGI
enables tubulin deacetylase activity IMP
IMP: Inferred from mutant phenotype
24334550 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
23502856 MGI
involved in cellular lipid catabolic process IMP
IMP: Inferred from mutant phenotype
19037106 MGI
involved in cellular response to caloric restriction IDA
IDA: Inferred from direct assay
17521387 MGI
involved in cellular response to epinephrine stimulus IDA
IDA: Inferred from direct assay
19037106 MGI
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
17521387 MGI
acts upstream of or within chromatin organization IGI
IGI: Inferred from genetic interaction
20562830 MGI
involved in epigenetic regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23908241 MGI
involved in myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
21949390 MGI
acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
23502856 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17681146 MGI
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
21949390 MGI
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
17521387 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17681146 MGI
involved in positive regulation of DNA binding IDA
IDA: Inferred from direct assay
17521387 MGI
involved in positive regulation of attachment of spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
24334550 MGI
involved in positive regulation of cell division IMP
IMP: Inferred from mutant phenotype
24334550 MGI
involved in positive regulation of execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
17521387 MGI
involved in positive regulation of meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
24334550 MGI
involved in positive regulation of oocyte maturation IMP
IMP: Inferred from mutant phenotype
24334550 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24681946 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17521387 MGI
involved in protein deacetylation IDA
IDA: Inferred from direct assay
17681146 MGI
involved in protein deacetylation IMP
IMP: Inferred from mutant phenotype
17521387 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
23126280 MGI
involved in regulation of myelination IMP
IMP: Inferred from mutant phenotype
21949390 MGI
acts upstream of or within tubulin deacetylation IGI
IGI: Inferred from genetic interaction
20562830 MGI
acts upstream of or within tubulin deacetylation IMP
IMP: Inferred from mutant phenotype
23126280 MGI
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
16933150 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11056054 MGI
located in meiotic spindle IDA
IDA: Inferred from direct assay
24334550 MGI
located in midbody IDA
IDA: Inferred from direct assay
24334550 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
26767982 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
16933150 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19037106 MGI
located in paranodal junction IDA
IDA: Inferred from direct assay
16933150 MGI
located in perikaryon IDA
IDA: Inferred from direct assay
16933150 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16933150 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt2 Protein Structure

SIRT1

SIRT1: cd01408 (76 - 330)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-2

  • NAD-dependent deacetylase sirtuin-2

  • NAD-dependent protein defatty-acylase sirtuin-2

  • SIR2-like protein 2

  • mSIR2L2

  • regulatory protein SIR2 homolog 2

  • silent mating type information regulation 2, (S.cerevisiae, homolog)-like

  • sirtuin 2

Sirt2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Sirt2 Q8VDQ8 AURKA Homo sapiens O14965
Anti Tag CoIP
22014574
Intra
Sirt2 Q8VDQ8 Fzr1 Mus musculus Q9R1K5
Anti Bait CoIP
22014574
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0150 Nicotinamide Inhibitor 99.98% Unkown
HY-B0879A Suramin sodium salt Inhibitor 99.98% Yes
HY-B0879 Suramin Inhibitor / Unkown
HY-B0150A Nicotinamide hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-B0150R Nicotinamide (Standard) Inhibitor 99.85% Phase 4

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10532 SRT 1720 Activator 99.90% Unkown
HY-100578 AGK2 Inhibitor 99.43% Unkown
HY-107454 OSS_128167 Inhibitor 98.92% Unkown
HY-13515 Sirtinol Inhibitor 98.0% Unkown
HY-100591 SirReal2 Inhibitor 99.0% Unkown
HY-16691 AK-7 Inhibitor 99.63% Unkown
HY-100732 Cambinol Inhibitor 99.89% Unkown
HY-15510 Tenovin-6 Inhibitor 98.00% Unkown
HY-101278 Thiomyristoyl Inhibitor 98.23% Unkown
HY-15145 SRT 1720 monohydrochloride Activator 99.92% Unkown
HY-101073 Salermide Inhibitor 98.0% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.15% Unkown
HY-103721 SIRT6-IN-2 Inhibitor 99.92% Unkown
HY-103636 PROTAC Sirt2 Degrader-1 Inhibitor 99.09% Unkown
HY-16605 SIRT6-IN-6 Inhibitor 98.59% Unkown
HY-N1926 Dihydrocoumarin Inhibitor 99.81% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% Unkown
HY-101465 AK-1 Inhibitor 99.84% Unkown
HY-112427 Sirt2-IN-1 Inhibitor 98.71% Unkown
HY-111522 RK-9123016 Inhibitor 99.65% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-107660 SIRT2-IN-8 Inhibitor 98.45% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.14% Unkown
HY-123653 SirReal-1 Inhibitor 99.82% Unkown
HY-146689 SIRT1-IN-2 Inhibitor 98.31% Unkown
HY-111329 JGB1741 Inhibitor 99.37% Unkown
HY-146690 SIRT1-IN-3 Inhibitor 99.12% Unkown
HY-163532 FLS-359 Modulator 95.41% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-107453 SirReal1-O-propargyl Ligand / Unkown
HY-147233 MIND4-19 Inhibitor 99.93% Unkown
HY-148408 SIRT2-IN-11 Inhibitor 99.94% Unkown
HY-118343 AC-93253 Inhibitor 99.3% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-160944 hsa62 Inhibitor / Unkown
HY-153509 Sirtuin-IN-1 Inhibitor / Unkown
HY-145958 Sirt2-IN-6 Inhibitor / Unkown
HY-149637 HSP70/SIRT2-IN-1 Inhibitor / Unkown
HY-185682 NCO-141 Inhibitor / Unkown
HY-W841840 SR94 Inhibitor / Unkown
HY-179388 PROTAC Sirt2 Degrader-2 Degrader / Unkown
HY-136713 Sirt1/2-IN-5 Inhibitor / Unkown
HY-150119 2'/3'-O-Acetyl-ADP-ribose sodium Substrate / Unkown
HY-114510 PRMT/HKMT-IN-1 / Unkown
HY-115979 Sirt2-IN-5 Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-114906 SIRT1/2/3-IN-2 Inhibitor / Unkown
HY-W197205 SL010110 Inhibitor / Unkown
HY-183870 NCO-90 Inhibitor / Unkown
HY-182412 NH4-6 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-W109401 SIRT-IN-6 Inhibitor / Unkown
HY-119889 A1B11 Inhibitor / Unkown
HY-178773 SIRT2-IN-18 Inhibitor / Unkown
HY-117442 A2B57 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt2 NCBI NCBI:22933