2. Gene
  3. Sirt2 - sirtuin 2 Gene

Sirt2 - sirtuin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sir2l; SIR2L2; 5730427M03Rik

Gene ID: 64383 | Gene type: protein coding

About Sirt2

Chromosome 7: 28,466,160-28,488,086 forward strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 187 orthologues, 6 paralogues and is associated with 24 phenotypes. Ubiquitous expression in testis adult (RPKM 56.8), cerebellum adult (RPKM 53.7) and 28 other tissues.

Summary

Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (Sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sirt2 Products(3)

mRNA Protein Name
NM_022432.4 NP_071877.3 NAD-dependent protein deacetylase sirtuin-2 isoform 1
NM_001122765.1 NP_001116237.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2
NM_001122766.1 NP_001116238.1 NAD-dependent protein deacetylase sirtuin-2 isoform 3

Sirt2 Protein Structure

SIRT1

SIRT1: cd01408 (76 - 330)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-2

NAD-dependent deacetylase sirtuin-2

NAD-dependent protein defatty-acylase sirtuin-2

SIR2-like protein 2

mSIR2L2

regulatory protein SIR2 homolog 2

silent mating type information regulation 2, (S.cerevisiae, homolog)-like

sirtuin 2

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0150 Nicotinamide Inhibitor 99.87% Yes
HY-B0879A Suramin sodium salt Inhibitor 99.48% Yes
HY-B0879 Suramin Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10532 SRT 1720 Activator 99.82% Unkown
HY-107454 OSS_128167 Inhibitor 98.63% Unkown
HY-15145 SRT 1720 monohydrochloride Activator 99.92% Unkown
HY-100578 AGK2 Inhibitor 99.62% Unkown
HY-13515 Sirtinol Inhibitor ≥98.0% Unkown
HY-101278 Thiomyristoyl Inhibitor 99.74% Unkown
HY-15510 Tenovin-6 Inhibitor 98.33% Unkown
HY-100732 Cambinol Inhibitor 99.89% Unkown
HY-16691 AK-7 Inhibitor 99.93% Unkown
HY-101073 Salermide Inhibitor ≥98.0% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.19% Unkown
HY-103636 PROTAC Sirt2 Degrader-1 Inhibitor 98.71% Unkown
HY-112427 Sirt2-IN-1 Inhibitor 98.45% Unkown
HY-146689 SIRT1-IN-2 Inhibitor 98.86% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor ≥98.0% Unkown
HY-101465 AK-1 Inhibitor 99.97% Unkown
HY-107660 SIRT2-IN-8 Inhibitor 99.32% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.58% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-111522 RK-9123016 Inhibitor 99.02% Unkown
HY-111329 JGB1741 Inhibitor 99.05% Unkown
HY-146690 SIRT1-IN-3 Inhibitor 99.18% Unkown
HY-147233 MIND4-19 Inhibitor 99.94% Unkown
HY-148408 SIRT2-IN-11 Inhibitor 99.94% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-115979 Sirt2-IN-5 Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown
HY-118343 AC-93253 Inhibitor / Unkown
HY-B0150R Nicotinamide (Standard) Inhibitor 99.85% Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-149637 HSP70/SIRT2-IN-1 Inhibitor / Unkown
HY-145958 Sirt2-IN-6 Inhibitor / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt2 NCBI NCBI:22933