SIRT2-IN-9
Based on 1 Customer Validation
SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.45%
- CAS No.: 522650-91-5
- Formule: C21H22N6OS2
- Masse moléculaire:438.57
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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SIRT2 1.3 μM (IC50) |
SIRT1 ＞300 μM (IC50) |
SIRT3 ＞300 μM (IC50) |
SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ＞300 μM[1]. SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells[1]. SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 breast cancer cell line
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Concentration:0-50 μM
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Incubation Time:72 hours
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Result:Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.
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Cell Line:MCF-7 breast cancer cell line
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Concentration:6.25, 12.5, 25 and 50 μM
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Incubation Time:6 hours
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Result:Dose-dependently increased acetylation of α-tubulin protein.
Chemical Information
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CAS No. 522650-91-5
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Appearance Solid
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Masse moléculaire 438.57
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Formule C21H22N6OS2
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Color Light yellow to yellow
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SMILES
O=C(NC1=NC(CCCC2)=C2S1)CSC3=NN=C4C(N(CCC)C5=C4C=CC=C5)=N3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
DMSO : 4.46 mg/mL (10.17 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2801 mL | 11.4007 mL | 22.8014 mL | 57.0034 mL |
| 5 mM | 0.4560 mL | 2.2801 mL | 4.5603 mL | 11.4007 mL | |
| 10 mM | 0.2280 mL | 1.1401 mL | 2.2801 mL | 5.7003 mL |
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