SIRT2-IN-9
Based on 1 Customer Validation
SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 522650-91-5
- Formula: C21H22N6OS2
- Molecular Weight:438.57
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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SIRT2 1.3 μM (IC50) |
SIRT1 ＞300 μM (IC50) |
SIRT3 ＞300 μM (IC50) |
SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ＞300 μM[1]. SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells[1]. SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 breast cancer cell line
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Concentration:0-50 μM
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Incubation Time:72 hours
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Result:Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.
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Cell Line:MCF-7 breast cancer cell line
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Concentration:6.25, 12.5, 25 and 50 μM
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Incubation Time:6 hours
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Result:Dose-dependently increased acetylation of α-tubulin protein.
Chemical Information
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CAS No. 522650-91-5
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Appearance Solid
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Molecular Weight 438.57
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Formula C21H22N6OS2
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Color Light yellow to yellow
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SMILES
O=C(NC1=NC(CCCC2)=C2S1)CSC3=NN=C4C(N(CCC)C5=C4C=CC=C5)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 4.46 mg/mL (10.17 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2801 mL | 11.4007 mL | 22.8014 mL | 57.0034 mL |
| 5 mM | 0.4560 mL | 2.2801 mL | 4.5603 mL | 11.4007 mL | |
| 10 mM | 0.2280 mL | 1.1401 mL | 2.2801 mL | 5.7003 mL |
SIRT2-IN-9 Related Classifications
HY-151519 Related Classifications
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