2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT2-IN-11

SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers.

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SIRT2-IN-11 Chemical Structure

SIRT2-IN-11 Chemical Structure

CAS No. : 1005095-06-6

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Based on 1 publication(s) in Google Scholar

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Description

SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].

IC50 & Target

SIRT2

18.5 μM (IC50)

SIRT1

118.4 μM (IC50)

In Vitro

SIRT2-IN-11 (0-1000 μM) shows inhibitory effect of SIRT2-dependent deacetylation of MAL with an IC50 value of 18.5 μM[1].
SIRT2-IN-11 (0-1000 μM) weakly inhibits SIRT1 with an IC50 value of 118.4 μM[1].
SIRT2-IN-11 (0-20 μM; 8 h) induces cell apoptosis of lung cancer cells[1].
SIRT2-IN-11 (20 μM; 6 h) increases p53 acetylation and expression levels of Cp53 target genes CDKN1A, PUMA and NOXA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIRT2-IN-11 Related Antibodies

RT-PCR[1]

Cell Line: NSCLC cell lines
Concentration: 20 μM
Incubation Time: 6 hours
Result: Increased the expression of CDKN1A, PUMA and NOXA.

Apoptosis Analysis[1]

Cell Line: A549 cell line
Concentration: 0, 0.5, 1, 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Mildly increased apoptosis of A549 cells, but when combined treatment with etoposide caused a marked increase in apoptosis.
Molecular Weight

318.41

Formula

C21H22N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C2NC(C3C(C4CCC3C4)C2=C1)C5=CC=CC=C5)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (785.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1406 mL 15.7030 mL 31.4060 mL
5 mM 0.6281 mL 3.1406 mL 6.2812 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1406 mL 15.7030 mL 31.4060 mL 78.5151 mL
5 mM 0.6281 mL 3.1406 mL 6.2812 mL 15.7030 mL
10 mM 0.3141 mL 1.5703 mL 3.1406 mL 7.8515 mL
15 mM 0.2094 mL 1.0469 mL 2.0937 mL 5.2343 mL
20 mM 0.1570 mL 0.7852 mL 1.5703 mL 3.9258 mL
25 mM 0.1256 mL 0.6281 mL 1.2562 mL 3.1406 mL
30 mM 0.1047 mL 0.5234 mL 1.0469 mL 2.6172 mL
40 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9629 mL
50 mM 0.0628 mL 0.3141 mL 0.6281 mL 1.5703 mL
60 mM 0.0523 mL 0.2617 mL 0.5234 mL 1.3086 mL
80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9814 mL
100 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
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SIRT2-IN-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT2-IN-111005095-06-6SirtuinapoptosisCDKN1APUMANOXAacetylationp53cancerInhibitorinhibitorinhibit

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